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Submissions from 2023

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Limosilactobacillus Fermentum 3872 That Produces Class III Bacteriocin Forms Co-aggregates with the Antibiotic-resistant Staphylococcus Aureus Strains and Induces Their Lethal Damage, Vyacheslav M. Abramov, Igor V. Kosarev, Andrey V. Machulin, Tatiana V. Priputnevich, Eugenia I. Deryusheva, Ekaterina L. Nemashkalova, Irina O. Chikileva, Tatiana N. Abashina, Alexander N. Panin, Vyacheslav G. Melnikov, Natalia E. Suzina, Ilya N. Nikonov, Marina V. Selina, Valentin S. Khlebnikov, Vadim K. Sakulin, Vladimir A. Samoilenko, Alexey B. Gordeev, Gennady T. Sukhikh, Vladimir N. Uversky, and Andrey V. Karlyshev

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Tuning the Aggregation Behavior of Human Insulin in the Presence of Luteolin: An in Vitro and in Silico Approach, Syed Moasfar Ali, Faisal Nabi, Mohammad Furkan, Malik Hisamuddin, Sadia Malik, Syed Mohammad Zakariya, Irum Rizvi, Vladimir N. Uversky, and Rizwan Hasan Khan

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Exploring the Mechanisms by Which Camel Lactoferrin Can Kill Salmonella Enterica Serovar Typhimurium And Shigella Sonnei, Hussein A. Almehdar, Nawal Abd El-Baky, Ehab H. Mattar, Raed S. Albiheyri, Atif Bamagoos, Abdullah A. AlJaddawi, Vladimir N. Uversky, and Elrashdy M. Redwan

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Current Therapeutic Approaches and Promising Perspectives of Using Bioengineered Peptides in Fighting Chemoresistance in Triple-negative Breast Cancer, Mandana Azari, Farbod Bahreini, Vladimir N. Uversky, and Nima Rezaei

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From the Hydrophobic Core to the Globular-disorder Interface: New Challenges and Insights Into Protein Design, Sankar Basu, Devlina Chakravarty, Qingzhen Hou, and Vladimir N. Uversky

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An Overview of the Vaccine Platforms to Combat COVID-19 with a Focus on the Subunit Vaccines, Fatemeh Bayani, Negin Safaei Hashkavaei, Sareh Arjmand, Shokouh Rezaei, Vuk Uskoković, Mahdi Alijanianzadeh, Vladimir N. Uversky, Seyed Omid Ranaei Siadat, Sina Mozaffari-Jovin, and Yahya Sefidbakht

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Liaisons Dangereuses: Intrinsic Disorder in Cellular Proteins Recruited to Viral Infection-related Biocondensates, Greta Bianchi, Stefania Brocca, Sonia Longhi, and Vladimir N. Uversky

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Advanced Phytochemical-based Nanocarrier Systems for the Treatment of Breast Cancer, Vivek P. Chavda, Lakshmi Vineela Nalla, Pankti Balar, Rajashri Bezbaruah, Vasso Apostolopoulos, Rajeev K. Singla, Avinash Khadela, Lalitkumar K. Vora, and Vladimir N. Uversky

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Paving the Way for Synthetic Intrinsically Disordered Polymers for Soft Robotics, Orkid Coskuner-Weber, Elif Yuce-Erarslan, and Vladimir N. Uversky

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Predicting TF Proteins by Incorporating Evolution Information Through PSSM, Zhihua Du, Tianyou Huang, Vladimir N. Uversky, and Jianqiang Li

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Yield and Composition Variations of the Milk from Different Camel Breeds in Saudi Arabia, Amr A. El-Hanafy, Yasser M. Saad, Saleh A. Alkarim, Hussein A. Almehdar, Fuad M. Alzahrani, Mohammed A. Almatry, Vladimir N. Uversky, and Elrashdy M. Redwan

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Pre-Molten, Wet, and Dry Molten Globules en Route to the Functional State of Proteins, Munishwar Nath Gupta and Vladimir N. Uversky

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Can COVID-19 Vaccines Induce Premature Non-communicable Diseases: Where Are We Heading To?, Altijana Hromić-Jahjefendić, Debmalya Barh, Vladimir N. Uversky, Alaa A. A. Aljabali, Murtaza M. Tambuwala, Fuad M. Alzahrani, Saleh Alshammeri, and Kenneth Lundstrom

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Biomolecular Condensates: Insights Into Early and Late Steps of the HIV-1 Replication Cycle, Francesca Di Nunzio, Vladimir N. Uversky, and Andrew J. Mouland

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Bioinformatics Insights on the Physicochemical Properties of SCN5A Mutant Proteins Associated with the Brugada Syndrome, Carlos Polanco, Manlio F. Márquez, Vladimir N. Uversky, Enrique Hernández Lemus, Alberto Huberman, Thomas Buhse, and Martha R. Castro

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On the Potential Therapeutic Roles of Taurine in Autism Spectrum Disorder, Alberto Rubio-Casillas, Elrashdy M. Redwan, and Vladimir N. Uversky

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SUMOylation-mediated PSME3-20S Proteasomal Degradation of Transcription Factor CP2c is Crucial for Cell Cycle Progression, Seung Han Son, Min Young Kim, Young Su Lim, Hyeon Cheol Jin, June Ho Shin, Jae Kyu Yi, Sungwoo Choi, Mi Ae Park, Ji Hyung Chae, Ho Chul Kang, Young Jin Lee, Vladimir N. Uversky, and Chul Geun Kim

Submissions from 2022

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Limosilactobacillus fermentum Strain 3872: Antibacterial and Immunoregulatory Properties and Synergy with Prebiotics Against Socially Significant Antibiotic-resistant Infections of Animals and Humans, Vyacheslav M. Abramov, Igor V. Kosarev, Andrey V. Machulin, Tatiana V. Priputnevich, Irina O. Chikileva, Eugenia I. Deryusheva, Tatiana N. Abashina, Almira D. Donetskova, Alexander N. Panin, Vyacheslav G. Melnikov, Natalia E. Suzina, Ilya N. Nikonov, Marina V. Selina, Valentin S. Khlebnikov, Vadim K. Sakulin, Raisa N. Vasilenko, Vladimir A. Samoilenko, Vladimir N. Uversky, and Andrey V. Karlyshev

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Aberrant Liquid-liquid Phase Separation and Amyloid Aggregation of Proteins Related to Neurodegenerative Diseases, Azeem Ahmad, Vladimir N. Uversky, and Rizwan Hasan Khan

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A Review on Biofilms and the Currently Available Antibiofilm Approaches: Matrix-destabilizing Hydrolases and Anti-bacterial Peptides as Promising Candidates for the Food Industries, Mohsen Akbarian, Shu-Hui Chen, Maryam Kianpour, Fatemeh Farjadian, Lobat Tayebi, and Vladimir N. Uversky

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Bioactive Peptides: Synthesis, Sources, Applications, and Proposed Mechanisms of Action, Mohsen Akbarian, Ali Khani, Sara Eghbalpour, and Vladimir N. Uversky

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Insights Into the Structural Properties of SARS-CoV-2 Main Protease, Ibrahim Y. Akbaryak, Sule I. Caglayan, Lukasz Kurgan, Vladimir N. Uversky, and Orkid Coskuner-Weber

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Circulating Extracellular Vesicles and Rheumatoid Arthritis: a Proteomic Analysis, Mohammed F. Alghamdi, Sultan Abdulmughni Alamry, Sami M. Bahlas, Vladimir N. Uversky, and Elrashdy M. Redwan

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Structures of the Wild-type and S59L Mutant CHCHD10 Proteins Important in Amyotrophic Lateral Sclerosis–frontotemporal Dementia, Hakan Alici, Vladimir N. Uversky, David E. Kang, Junga Alexa Woo, and Orkid Coskuner-Weber

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Brain Metabolite, Myo-inositol, Inhibits Catalase Activity: A Mechanism of the Distortion of the Antioxidant Defense System in Alzheimer’s Disease, Fasil Ali, Usma Manzoor, Reshmee Bhattacharya, Aniket Kumar Bansal, Kempohalli Sayanna Chandrashekharaiah, Laishram Rajendrakumar Singh, Suma Mohan Saraswati, Vladimir N. Uversky, and Tanveer Ali Dar

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MSH3 Homology and Potential Recombination Link to SARS-CoV-2 Furin Cleavage Site, Balamurali K. Ambati, Akhil Varshney, Kenneth Lundstrom, Giorgio Palù, Bruce D. Uhal, Vladimir N. Uversky, and Adam M. Brufsky

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Identification of Intrinsically Disorder Regions in Non-structural Proteins of SARS-CoV-2: New Insights Into Drug and Vaccine Resistance, Farah Anjum, Taj Mohammad, Purva Asrani, Alaa Shafie, Shailza Singh, Dharmendra Kumar Yadav, Vladimir N. Uversky, and Md Imtaiyaz Hassan

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Liquid–liquid Phase Separation as an Organizing Principle of Intracellular Space: Overview of the Evolution of the Cell Compartmentalization Concept, Iuliia A. Antifeeva, Alexander V. Fonin, Anna S. Fefilova, Olesia V. Stepanenko, Olga I. Povarova, Sergey A. Silonov, Irina M. Kuznetsova, Vladimir N. Uversky, and Konstantin K. Turoverov

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BIAPSS: A Comprehensive Physicochemical Analyzer of Proteins Undergoing Liquid–liquid Phase Separation, Aleksandra E. Badaczewska-Dawid, Vladimir N. Uversky, and Davit A. Potoyan

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Insights Into the Structural Peculiarities of The N-terminal and Receptor Binding Domains of the Spike Protein from the SARS-CoV-2 Omicron Variant, Fatemeh Bayani, Negin Safaei Hashkavaei, Vladimir N. Uversky, Sina Mozaffari-Jovin, and Yahya Sefidbakht

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Comparative Study of Structures and Functional Motifs in Lectins from the Commercially Important Photosynthetic Microorganisms, Raquel P. Bezerra, Amanda S. Conniff, and Vladimir N. Uversky

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Ferritinophagy and α-synuclein: Pharmacological Targeting of Autophagy to Restore Iron Regulation in Parkinson’s Disease, Matthew K. Boag, Angus Roberts, Vladimir N. Uversky, Linlin Ma, Des R. Richardson, and Dean L. Pountney

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Intrinsically Disordered Proteins Play Diverse Roles in Cell Signaling, Sarah E. Bondos, A. Keith Dunker, and Vladimir N. Uversky

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COVID-19 and Vaccination: Myths Vs Science, Vivek P. Chavda, Yangmin Chen, Jayant Dave, Zhe-Sheng Chen, Subhash C. Chauhan, Murali M. Yallapu, Vladimir N. Uversky, Rajashri Bezbaruah, Sandip Patel, and Vasso Apostolopoulos

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Nitric Oxide and Its Derivatives Containing Nasal Spray and Inhalation Therapy for the Treatment of COVID-19, Vivek P. Chavda, Aayushi B. Patel, Lalitkumar K. Vora, Rajeev K. Singla, Priyal Shah, Vladimir N. Uversky, and Vasso Apostolopoulos

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Therapeutic Monoclonal Antibodies for COVID-19 Management: an Update, Vivek P. Chavda, Riddhi Prajapati, Disha Lathigara, Bhumi Nagar, Jay Kukadiya, Elrashdy M. Redwan, Vladimir N. Uversky, Mukesh N. Kher, and Rajvi Patel

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From Quantum Mechanics, Classical Mechanics, and Bioinformatics to Artificial Intelligence Studies in Neurodegenerative Diseases, Orkid Coskuner-Weber, M. Gokhan Habiboglu, David Teplow, and Vladimir N. Uversky

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Intrinsically Disordered Proteins and Proteins with Intrinsically Disordered Regions in Neurodegenerative Diseases, Orkid Coskuner-Weber, Ozan Mirzanli, and Vladimir N. Uversky

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Rapid Prediction and Analysis of Protein Intrinsic Disorder, Guy W. Dayhoff II and Vladimir N. Uversky

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Design and Analysis of a Mutant Form of the Ice-binding Protein From Choristoneura Fumiferana, Anna A. Deeva, Ksenia A. Glukhova, Lala S. Isoyan, Yuliya D. Okulova, Vladimir N. Uversky, and Bogdan S. Melnik

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α-Synuclein Fibrils as Penrose Machines: A Chameleon in the Gear, Francesca De Giorgi, Vladimir N. Uversky, and François Ichas

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Peptidoglycan-free Bacterial Ghosts Confer Enhanced Protection Against Yersinia Pestis Infection, Svetlana V. Dentovskaya, Anastasia S. Vagaiskaya, Mikhail E. Platonov, Alexandra S. Trunyakova, Sergey A. Kotov, Ekaterina A. Krasil’nikova, Galina M. Titareva, Elizaveta M. Mazurina, Tat’yana V. Gapel’chenkova, Rima Z. Shaikhutdinova, Sergey A. Ivanov, Tat’yana I. Kombarova, Vladimir N. Gerasimov, Vladimir N. Uversky, and Andrey P. Anisimov

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Looking at the Pathogenesis of the Rabies Lyssavirus Strain Pasteur Vaccins Through a Prism of the Disorder-based Bioinformatics, Surya Dhulipala and Vladimir N. Uversky

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Intrinsic Disorder in BAP1 and Its Association with Uveal Melanoma, Mak B. Djulbegovic, David J. Taylor, Vladimir N. Uversky, Anat Galor, Carol L. Shields, and Carol L. kARP

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The Aqueous Humor Proteome is Intrinsically Disordered, Mak B. Djulbegovic and Vladimir N. Uversky

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Functional Impact of Titin (TTN) Mutations in Ocular Surface Squamous Neoplasia, Mak B. Djulbegovic, Vladimir N. Uversky, Carol L. Karp, and J. William Harbour

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DeepA-rbpbs: A Hybrid Convolution and Recurrent Neural Network Combined with Attention Mechanism for Predicting RBP Binding Site, Zhihua Du, Xiangdong Xiao, and Vladimir N. Uversky

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Inference of Gene Regulatory Networks Based on the Light Gradient Boosting Machine, Zhihua Du, Xing Zhong, Fangzhong Wang, and Vladimir N. Uversky

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Fundamental Clock of Biological Aging: Convergence of Molecular, Neurodegenerative, Cognitive and Psychiatric Pathways: Non-equilibrium Thermodynamics Meet Psychology, Victor V. Dyakin, Nuka V. Dyakina-Fagnano, Laura B. Mcintire, and Vladimir N. Uversky

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Arrow of Time, Entropy, and Protein Folding: Holistic View on Biochirality, Victor V. Dyakin and Vladimir N. Uversky

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Deepcld: An Efficient Sequence-based Predictor of Intrinsically Disordered Proteins, Min Fang, Yufeng He, Zhihua Du, and Vladimir N. Uversky

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Identification of SARS-CoV-2 Surface Therapeutic Targets and Drugs Using Molecular Modeling Methods for Inhibition of the Virus Entry, Sadegh Farhadian, Ehsan Heidari-Soureshjani, Fatemeh Hashemi-Shahraki, Ali Hasanpour-Dehkordi, Vladimir N. Uversky, Majid Shirani, Behzad Shareghi, Mehraban Sadeghi, Esmaeil Pirali, and Saeid Hadi-Alijanvand

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Biological Soft Matter: Intrinsically Disordered Proteins in Liquid–liquid Phase Separation and Biomolecular Condensates, Alexander V. Fonin, Iuliia A. Antifeeva, Irina M. Kuznetsova, Konstantin K. Turoverov, Boris Zaslavsky, Prakash Kulkarni, and Vladimir N. Uversky

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New Evidence of the Importance of Weak Interactions in the Formation of PML-bodies, Alexander V. Fonin, Sergey A. Silonov, Anna S. Fefilova, Olesya V. Stepanenko, Anastasia A. Gavrilova, Alexey V. Petukhov, Anna E. Romanovich, Anna L. Modina, Tatiana S. Zueva, Evgeniy M. Nedelyaev, Nadejda M. Pleskach, Irina M. Kuznetsova, Vladimir N. Uversky, Konstantin K. Turoverov, and Mirya L. Kuranova

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Intrinsic Disorder in Proteins Associated with Oxidative Stress-induced JNK Signaling, Bhuvaneshwari R. Gehi, Kundlik Gadhave, Vladimir N. Uversky, and Rajanish Giri

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A Study on the Nature of SARS-CoV-2 Using the Shell Disorder Models: Reproducibility, Evolution, Spread, and Attenuation, Gerard Kian-Meng Goh, A. Keith Dunker, James A. Foster, and Vladimir N. Uversky

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Computational, Experimental, and Clinical Evidence of a Specific But Peculiar Evolutionary Nature of (COVID-19) SARS-CoV-2, Gerard Kian-Meng Goh, A. Keith Dunker, James A. Foster, and Vladimir N. Uversky

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Shell Disorder Models Detect That Omicron Has Harder Shells with Attenuation but Is Not a Descendant of the Wuhan-Hu-1 SARS-CoV-2, Gerard Kian-Meng Goh, A. Keith Dunker, James A. Foster, and Vladimir N. Uversky

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Shell Disorder and the HIV Vaccine Mystery: Lessons from the Legendary Oswald Avery, Gerard Kian-Meng Goh and Vladimir N. Uversky

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On the Potential Significance of the Intrinsically Disordered Regions in The Clostridiodes Difficile Toxins A and B, Nashwa El Hadidy, Vladimir N. Uversky, and Xingmin Sun

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The Amyloid State of Proteins: A Boon Or Bane?, Md Nadir Hassan, Faisal Nabi, Asra Nasir Khan, Murtaza Hussain, Waseem A. Siddiqui, Vladimir N. Uversky, and Rizwan Hasan Khan

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The Importance of Accessory Protein Variants in the Pathogenicity of SARS-CoV-2, Sk. Sarif Hassan, Pabitra Pal Choudhury, Guy W. Dayhoff, Alaa A.A. Aljabali, Bruce D. Uhal, Kenneth Lundstrom, Nima Rezaei, Damiano Pizzol, Parise Adadi, Amos Lal, Antonio Soares, Tarek Mohamed Abd El-Aziz, Adam M. Brufsky, Gajendra Kumar Azad, Samendra P. Sherchan, Wagner Baetas-da-Cruz, Kazuo Takayama, Ãngel Serrano-Aroca, Gaurav Chauhan, Giorgio Palu, Yogendra Kumar Mishra, Debmalya Barh, Raner Jośe Santana Silva, Bruno Silva Andrade, Vasco Azevedo, Aristóteles Góes-Neto, Nicolas G. Bazan, Elrashdy M. Redwan, Murtaza Tambuwala, and Vladimir N. Uversky

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An Issue of Concern: Unique Truncated ORF8 Protein Variants of SARS-CoV-2, Sk. Sarif Hassan, Vaishnavi Kodakandla, Elrashdy M. Redwan, Kenneth Lundstrom, Pabitra Pal Choudhury, Tarek Mohamed El-Aziz, Kazuo Takayama, Ramesh Kandimalla, Amos Lal, Ángel Serrano-Aroca, Gajendra Kumar Azad, Alaa A.A. Aljabali, Giorgio Palù, Gaurav Chauhan, Parise Adadi, Murtaza Tambuwala, Adam M. Brufsky, Wagner Baetas-da-Cruz, Debmalya Barh, Vasco Azevedo, Nikolas G. Bazan, Bruno Silva Andrade, Raner José Silva, and Vladimir N. Uversky

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Non-uniform Aspects of the SARS-CoV-2 Intraspecies Evolution Reopen Question of Its Origin, Sk. Sarif Hassan, Vaishnavi Kodakandla, Elrashdy M. Redwan, Kenneth Lundstrom, Pabitra Pal Choudhury, Ángel Serrano-Aroca, Gajendra Kumar Azad, Alaa A.A. Aljabali, Giorgio Palu, Tarek Mohamed Abd El-Aziz, Debmalya Barh, Bruce D. Uhal, Parise Adadi, Kazuo Takayama, Nicolas G. Bazan, Murtaza Tambuwala, Samendra P. Sherchan, Amos Lal, Gaurav Chauhan, Wagner Baetas-da-Cruz, and Vladimir N. Uversky

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Emergence of Unique SARS-CoV-2 ORF10 Variants and Their Impact on Protein Structure and Function, Sk. Sarif Hassan, Kenneth Lundstrom, Ángel Serrano-Aroca, Parise Adadi, Alaa A.A. Aljabali, Elrashdy M. Redwan, Amos Lal, Ramesh Kandimalla, Tarek Mohamed El-Aziz, Pabitra Pal Choudhury, Gajendra Kumar Azad, Samendra P. Sherchan, Gaurav Chauhan, Murtaza Tambuwala, Kazuo Takayama, Debmalya Barh, Giorgio Palu, Pallab Basu, and Vladimir N. Uversky

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Possible Functional Proximity of Various Organisms Based on the Bioinformatics Analysis of Their Taste Receptors, Sk. Sarif Hassan, Moumita Sil, Subhajit Chakraborty, Arunava Goswami, Pallab Basu, Debaleena Nawn, and Vladimir N. Uversky

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BMI1 Silencing Induces Mitochondrial Dysfunction in Lung Epithelial Cells Exposed to Hyperoxia, Helena Hernández-Cuervo, Ramani Soundararajan, Sahebgowda Sidramagowda Patil, Mason T. Breitzig, Matthew Alleyn, Lakshmi Galam, Richard Lockey, Vladimir N. Uversky, and Narasaiah Kolliputi

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Associations and Disease–disease Interactions of COVID-19 with Congenital and Genetic Disorders: A Comprehensive Review, Altijana Hromić-Jahjefendić, Debmalya Barh, Cecília Horta Ramalho Pinto, Lucas Gabriel Rodrigues Gomes, Jéssica Lígia Picanço Machado, Oladapo Olawale Afolabi, Sandeep Tiwari, Alaa A.A. Aljabali, Murtaza M. Tambuwala, Ángel Serrano-Aroca, Elrashdy M. Redwan, Vladimir N. Uversky, and Kenneth Lundstrom

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An Ayurgenomics Approach: Prakriti-based Drug Discovery and Development for Personalized Care, Zoufang Huang, Vivek P. Chavda, Rajashri Bezbaruah, Vladimir N. Uversky, Sucharitha Palagati, Aayushi B. Patel, and Zhe-Sheng Chen

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Age-dependent Aggregation of α-synuclein in the Nervous System of Gut-brain Axis is Associated with Caspase-1 Activation, Qi Hu, Mei Hong, Mengyang Huang, Quan Gong, Xiaofan Zhang, Vladimir N. Uversky, Francisco Pan-Montojo, Teng Huang, Honglian Zhou, and Suiqiang Zhu

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Role of Structural Disorder in the Multi-functionality of Flavivirus Proteins, Shivani K. Kapuganti, Aparna Bhardwaj, Prateek Kumar, Taniya Bhardwaj, Namyashree Nayak, Vladimir N. Uversky, and Rajanish Giri

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Calcium-bound S100P Protein Is a Promiscuous Binding Partner of the Four-helical Cytokines, Alexey S. Kazakov, Eugenia I. Deryusheva, Maria E. Permyakova, Andrey S. Sokolov, Victoria A. Rastrygina, Vladimir N. Uversky, Eugene A. Permyakov, and Sergei E. Permyakov

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Erythropoietin Interacts with Specific S100 Proteins, Alexey S. Kazakov, Eugenia I. Deryusheva, Andrey S. Sokolov, Maria E. Permyakova, Ekaterina A. Litus, Victoria A. Rastrygina, Vladimir N. Uversky, Eugene A. Permyakov, and Sergei E. Permyakov

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Interferon-β Activity Is Affected by S100B Protein, Alexey S. Kazakov, Alexander D. Sofin, Nadezhda V. Avkhacheva, Eugenia I. Deryusheva, Victoria A. Rastrygina, Maria E. Permyakova, Vladimir N. Uversky, Eugene A. Permyakov, and Sergei E. Permyakov

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Specific Cytokines of Interleukin-6 Family Interact with S100 Proteins, Alexey S. Kazakov, Andrey S. Sokolov, Maria E. Permyakova, Ekaterina A. Litus, Vladimir N. Uversky, Eugene A. Permyakov, and Sergei E. Permyakov

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Specific S100 Proteins Bind Tumor Necrosis Factor and Inhibit Its Activity, Alexey S. Kazakov, Marina Y. Zemskova, Gleb K. Rystsov, Alisa A. Vologzhannikova, Eugenia I. Deryusheva, Victoria A. Rastrygina, Andrey S. Sokolov, Maria E. Permyakova, Ekaterina A. Litus, Vladimir N. Uversky, Eugene A. Permyakov, and Sergei E. Permyakov

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Nanoparticles for Coronavirus Control, Maryam Kianpour, Mohsen Akbarian, and Vladimir N. Uversky

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On the Origin of Matrix Mechanism in Protocells and Key Problems of Molecular Biologyon the Origin of Matrix Mechanism in Protocells and Key Problems of Molecular Biology, Eduard Y. Kostetsky and Vladimir N. Uversky

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Co-opting Disorder Into Order: Intrinsically Disordered Proteins and the Early Evolution of Complex Multicellularity, Prakash Kulkarni, Amita Behal, Pranab Mohanty, and Atish Mohanty

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Intrinsically Disordered Proteins: Critical Components of the Wetware, Prakash Kulkarni, Supriyo Bhattacharya, Srisairam Achuthan, Amita Behal, Mohit Kumar Jolly, Sourabh Kotnala, Atish Mohanty, Govindan Rangarajan, Ravi Salgia, and Vladimir N. Uversky

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Intrinsically Disordered Proteins: Ensembles at the Limits of Anfinsen's Dogma, Prakash Kulkarni, Vitor B. P. Leite, Susmita Roy, Supriyo Bhattacharyya, Atish Mohanty, Srisairam Achuthan, Divyoj Singh, Rajeswari Appadurai, Govindan Rangarajan, Keith Weninger, John Orban, Anand Srivastava, Mohit Kumar Jolly, José N. Onuchic, Vladimir N. Uversky, and Ravi Salgia

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Intrinsically Disordered BMP4 Morphogen and the Beak of the Finch: Co-option of an Ancient Axial Patterning System, Prakash Kulkarni, Atish Mohanty, Ravi Salgia, and Vladimir N. Uversky

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Bayesian Molecular Dating Analyses Combined with Mutational Profiling Suggest an Independent Origin and Evolution of SARS-CoV-2 Omicron BA.1 and BA.2 Sub-Lineages, Naveen Kumar, Rahul Kaushik, Ashutosh Singh, Vladimir N. Uversky, Kam Y. J. Zhang, Upasana Sahu, Sandeep Bhatia, and Aniket Sanyal

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Editorial: Emerging and Re-emerging Viral Zoonoses, Naveen Kumar, Vladimir N. Uversky, Shailly Tomar, Kenneth S. M. Li, Keith Chappell, and Susanna K. P. Lau

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Effect of Protein–protein Interactions on Translational Diffusion of Spheroidal Proteins, Aleksandra M. Kusova, Aleksandr E. Sitnitsky, Vladimir N. Uversky, and Yuriy F. Zuev

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Ibuprofen Favors Binding of Amyloid-β Peptide to Its Depot, Serum Albumin, Ekaterina A. Litus, Alexei S. Kazakov, Eugenia I. Deryusheva, Ekaterina L. Nemashkalova, Marina P. Shevelyova, Andrey V. Machulin, Aliya A. Nazipova, Maria E. Permyakova, Vladimir N. Uversky, and Sergei E. Permyakov

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PyPAn: An Automated Graphical User Interface for Protein Sequence and Structure Analyses, Yash Mathur, Taj Mohammad, Farah Anjum, Alaa Shafie, Abdelbaset M. Elasbali, Vladimir N. Uversky, and Md. Imtaiyaz Hassan

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Structural Characterisation of Amyloidogenic Intrinsically Disordered Zinc Finger Protein Isoforms DPF3b and DPF3a, Julien Mignon, Denis Mottet, Tanguy Leyder, Vladimir N. Uversky, Eric A. Perpète, and Catherine Michaux

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Intrinsic Disorder as a Natural Preservative: High Levels of Intrinsic Disorder in Proteins Found in the 2600-year-old Human Brain, Aaron S. Mohammed and Vladimir N. Uversky

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Computational Studies on Phylogeny and Drug Designing Using Molecular Simulations for COVID-19, Faisal Nabi, Owais Ahmad, Yawar Ali Khan, Anas Nabi, Hashmi Md Amiruddin, Faizan Abul Qais, Aiman Masroor, Malik Hisamuddin, Vladimir N. Uversky, and Rizwan Hasan Khan

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Phase Separation of FG-nucleoporins in Nuclear Pore Complexes, Niharika Nag, Santanu Sasidharan, Vladimir N. Uversky, Prakash Saudagar, and Timir Tripathi

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Small Heat Shock Protein 22 Improves Cognition and Learning in the Tauopathic Brain, Santiago Rodriguez Ospina, Danielle M. Blazier, Marangelie Criado-Marrero, Lauren A. Gould, Niad T. Gebru, David Beaulieu-Abdelahad, Xinming Wang, Elizabeth Remily-Wood, Dale Chaput, Stanley Stevens Jr., Vladimir N. Uversky, Paula C. Bickford, Chad Anthony Dickey, and Laura J. Blair

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What Is Parvalbumin For?, Eugene A. Permyakov and Vladimir N. Uversky

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Lighting Up Nobel Prize-winning Studies with Protein Intrinsic Disorder, Lolita Piersimoni; el Malek, Abd el Malek; Twinkle Bhatia; Julian Bender; Christin Brankatschk; Sánchez, Jaime Calvo Sánchez; Guy W. Dayhoff; Ianni, Alessio Di Ianni; Parra, Jhonny Figueroa Parra; Dailen Garcia-Martinez; Julia Hesselbarth; Janett Köppen; Luca M. Lauth; Laurin Lippik; Lisa Machner; Shubhra Sachan; Lisa Schmidt; Robin Selle; Ioannis Skalidis; Oleksandr Sorokin; Daniele Ubbiali; Bruno Voigt; Alice Wedler; Alan An Wei; Peter Zorn; Alan Keith Dunker; Marcel Köhn; Andrea Sinz; and Vladimir N. Uversky

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Bioinformatics-based Characterization of Proteins Related to SARS-CoV- 2 Using the Polarity Index Method® (PIM®) and Intrinsic Disorder Predisposition, Carlos Polanco, Vladimir N. Uversky, Guy W. Dayhoff, Alberto Huberman, Thomas Buhse, Manlio F. Márquez, Gilberto Vargas-Alarcón, Jorge Alberto Castañón-González, Leire Andrés, Juan Luciano Dı́az-González, and Karina González-Bañales

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Bioinformatics-based Characterization of the Sequence Variability of Zika Virus Polyprotein and Envelope Protein (E), Carlos Polanco, Vladimir N. Uversky, Alberto Huberman, Gilberto Vargas-Alarcón, Jorge Alberto Castañón González, Thomas Buhse, Enrique Hernández Lemus, Martha Rios Castro, Erika Jeannette López Oliva, and Sergio Enrique Solís Nájera

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Characterization of Proteins from Putative Human DNA and RNA Viruses, Carlos Polanco, Vladimir N. Uversky, Gilberto Vargas-Alarcón, Thomas Buhse, Alberto Huberman, Manlio F. Márquez, and Leire Andrés

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Theater in the Self-cleaning Cell: Intrinsically Disordered Proteins or Protein Regions Acting with Membranes in Autophagy, Hana Popelka and Vladimir N. Uversky

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Hepatitis C Virus Infection and Intrinsic Disorder in the Signaling Pathways Induced by Toll-like Receptors, Elrashdy M. Redwan, Abdullah A. Aljadawi, and Vladimir N. Uversky

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Would New SARS-CoV-2 Variants Change the War against COVID-19?, Elrashdy M. Redwan, Fatma Elrashdy, Alaa A.A. Aljabali, Wagner Baetas-da-Cruz, Debmalya Barh, Adam M. Brufsky, Sk. Sarif Hassan, Kenneth Lundstrom, Ángel Serrano-Aroca, Kazuo Takayama, Murtaza M. Tambuwala, Bruce D. Uhal, and Vladimir N. Uversky