Intrinsically Disordered Proteins and Proteins with Intrinsically Disordered Regions in Neurodegenerative Diseases
Document Type
Article
Publication Date
2022
Keywords
Intrinsically Disordered Proteins, Proteins with Intrinsically Disordered Regions, Neurodegeneration, Pathology, Drug Design
Digital Object Identifier (DOI)
https://doi.org/10.1007/s12551-022-00968-0
Abstract
Many different intrinsically disordered proteins and proteins with intrinsically disordered regions are associated with neurodegenerative diseases. These types of proteins including amyloid-β, tau, α-synuclein, CHCHD2, CHCHD10, and G-protein coupled receptors are increasingly becoming evaluated as potential drug targets in the pharmaceutical-based treatment approaches. Here, we focus on the neurobiology of this class of proteins, which lie at the center of numerous neurodegenerative diseases, such as Alzheimer’s and Parkinson’s diseases, Huntington’s disease, amyotrophic lateral sclerosis, frontotemporal dementia, Charcot–Marie–Tooth diseases, spinal muscular atrophy, and mitochondrial myopathy. Furthermore, we discuss the current treatment design strategies involving intrinsically disordered proteins and proteins with intrinsically disordered regions in neurodegenerative diseases. In addition, we emphasize that although the G-protein coupled receptors are traditionally investigated using structural biology-based models and approaches, current studies show that these receptors are proteins with intrinsically disordered regions and therefore they require new ways for their analysis.
Was this content written or created while at USF?
Yes
Citation / Publisher Attribution
Biophysical Reviews, v. 14, p. 679-707
Scholar Commons Citation
Coskuner-Weber, Orkid; Mirzanli, Ozan; and Uversky, Vladimir N., "Intrinsically Disordered Proteins and Proteins with Intrinsically Disordered Regions in Neurodegenerative Diseases" (2022). Molecular Medicine Faculty Publications. 958.
https://digitalcommons.usf.edu/mme_facpub/958
