Liquid–liquid Phase Separation, Membrane-less Organelles, and Biomolecular Condensates in Cardiovascular Disease
Document Type
Book Chapter
Publication Date
2023
Keywords
Biomolecules, Cardiovascular Disease, Intrinsically Disordered Protein, Liquid–liquid Phase Separation, Membrane-less Organelle, Molecular Biology, Nervous System Disorder, Proteomics, Structural Classification of Proteins
Digital Object Identifier (DOI)
https://doi.org/10.1016/B978-0-12-823967-4.00007-5
Abstract
Cardiovascular disease (CVD), a group of diseases of the heart and blood vessels, is one of the leading causes of global mortality and morbidity in the world. In addition, it also represents a major economic burden on healthcare systems in terms of direct and indirect costs, considering the costs of drugs, hospitalizations, physician visits, and rehabilitation services on the one hand, and looking at the losses of productivity due to the short- or long-term disability and premature mortality on the other hand. Due to the breadth of the CVD manifestations and the ability of this disease to differently affect different organs, there is no universal cure for CVD and instead treatments vary widely. Many proteins associated with CVD pathogenesis are intrinsically disordered (IDPs) or contain long intrinsically disordered regions (IDRs). Among various important features of several IDPs/IDRs is their capability to undergo liquid–liquid phase separation (LLPS), which is critically related to the biogenesis of various membrane-less organelles (MLOs). Although importance of various MLOs in neurodegeneration and cancer is studied rather well, known examples of the roles of the distorted LLPS and aberrant biogenesis MLOs in CVD pathogenesis are rather limited. This chapter describes several instances where LLPS and MLOs were linked to CVD.
Was this content written or created while at USF?
Yes
Citation / Publisher Attribution
Liquid–liquid Phase Separation, Membrane-less Organelles, and Biomolecular Condensates in Cardiovascular Disease, in V. N. Uversky (Ed.), Droplets of Life, Academic Press, p. 663-679
Scholar Commons Citation
Uversky, Vladimir N., "Liquid–liquid Phase Separation, Membrane-less Organelles, and Biomolecular Condensates in Cardiovascular Disease" (2023). Molecular Medicine Faculty Publications. 1125.
https://digitalcommons.usf.edu/mme_facpub/1125
