Submissions from 2019
Structure Determination by Single-particle Cryo-electron Microscopy: Only the Sky (and Intrinsic Disorder) is the Limit, Emeka Nwanochie and Vladimir N. Uversky
Introduction to Intrinsically Disordered Proteins and Regions, Christopher J. Oldfield, Vladimir N. Uversky, A. Keith Dunker, and Lukasz Kurgan
Perturbation of Water Structure by Water-polymer Interactions Probed by FTIR and Polarized Raman Spectroscopy, Jessica Pavelec, David DiGuiseppi, Boris Y. Zavlavsky, Vladimir N. Uversky, and Reinhard Schweitzer-Stenner
Heteroaryl Phosphonates as Noncovalent Inhibitors of Both Serine- and Metallocarbapenemases, Orville A. Pemberton, Priyadarshini Jaishankar, Afroza Akhtar, Jessie L. Adams, Lindsey N. Shaw, Adam R. Renslo, and Yu Chen
Analyzing the Structural and Functional Roles of Residues from the ‘black’ and ‘gray’ Clusters of Human S100P Protein, Maria E. Permyakova, Sergei E. Permyakov, Alexei S. Kazakov, Alexander I. Denesyuk, Konstantin Denessiouk, Vladimir N. Uversky, and Eugene A. Permyakov
Experimental Insight Into the Structural and Functional Roles of the ‘Black’ and ‘Gray’ Clusters in Recoverin, a Calcium Binding Protein with Four EF-Hand Motifs, Sergei E. Permyakov, Alisa S. Vologzhannikova, Ekaterina L. Nemashkalova, Alexei S. Kazakov, Alexander I. Denesyuk, Konstantin Denessiouk, Viktoriia E. Baksheeva, Andrey A. Zamyatnin Jr., Eugene Yu. Zernii, Vladimir N. Uversky, and Eugene A. Permyakov
Bioinformatics Analysis of Dysfunctional (Mutated) Proteins of Cardiac Ion Channels Underlying the Brugada Syndrome, Carlos Polanco, Manlio F. Márquez, Vladimir N. Uversky, Thomas Buhse, and Miquel Estrada
Bioinformatics haracterisation of the (mutated) Proteins Related to Andersen–Tawil Syndrome, Carlos Polanco, Vladimir N. Uversky, Manlio F. Márquez, Thomas Buhse, Miguel Arias Estrada, and Alberto Huberman
Characterization of an Extensive Interface on Vitronectin for Binding to Plasminogen Activator Inhibitor-1: Adoption of Structure in an Intrinsically Disordered Region, Letitia O. Puster, Christopher B. Stanley, Vladimir N. Uversky, Joseph E. Curtis, Susan Krueger, Yuzhuo Chu, and Cynthia B. Peterson
Structural Disorder in the Proteome and Interactome of Alkhurma Virus (ALKV), Elrashdy M. Redwan, Abdullah A. AlJaddawi, and Vladimir N. Uversky
IFI16, a Nuclear Innate Immune DNA Sensor, Mediates Epigenetic Silencing of Herpesvirus Genomes by its Association with H3K9 methyltransferases SUV39H1 and GLP, Arunava Roy, Anandita Ghosh, Binod Kumar, and Bala Chandran
Stabilizing Proteins to Prevent Conformational Changes Required for Amyloid Fibril Formation, Mohammad Khursheed Siddiqi, Parvez Alam, Sadia Malik, Nabeela Majid, Sumit Kumar Chaturvedi, Sudeepa Rajan, Mohd Rehan Ajmal, Mohsin Vahid Khan, Vladimir N. Uversky, and Rizwan Hasan Khan
5-Aminolevulinate Synthase Catalysis: The Catcher in Heme Biosynthesis, Bosko M. Stojanovski, Gregory A. Hunter, Insung Na, Vladimir N. Uversky, Rays H.Y. Jiang, and Gloria C. Ferreira
Stochasticity of Biological Soft Matter: Emerging Concepts in Intrinsically Disordered Proteins and Biological Phase Separation, Konstantin K. Turoverov, Irina M. Kuznetsova, Alexander V. Fonin, April L. Darling, Boris Y. Zaslavsky, and Vladimir N. Uversky
Intrinsically Disordered Proteins and Their “Mysterious” (Meta)Physics, Vladimir N. Uversky
Protein Intrinsic Disorder and Structure-function Continuum, Vladimir N. Uversky
Supramolecular Fuzziness of Intracellular Liquid Droplets: Liquid–liquid Phase Transitions, Membrane-less Organelles, and Intrinsic Disorder, Vladimir N. Uversky
Torches, Candles, Lamps, Lanterns, Flashlights, Spotlights, Night Vision Goggles… You Need Them All to See in Darkness, Vladimir N. Uversky
Life in Phases: Intra- and Inter- Molecular Phase Transitions in Protein Solutions, Vladimir N. Uversky and Alexey V. Finkelstein
On the Need to Develop Guidelines for Characterizing and Reporting Intrinsic Disorder in Proteins, Michael Vincent, Vladimir N. Uversky, and Santiago Schnell
Effects of His-tags on Physical Properties of Parvalbumins, Alisa A. Vologzhannikova, Polina A. Khorn, Alexei S. Kazakov, Eugene A. Permyakov, Vladimir N. Uversky, and Sergei E. Permyakov
Small Heat Shock Proteins, Big Impact on Protein Aggregation in Neurodegenerative Disease, Jack M. Webster, April L. Darling, Vladimir N. Uversky, and Laura J. Blair
Differential Long-term Regulation of TAS2R14 by Structurally Distinct Agonists, Jung A. Woo, Maria Castaño, Ashley Goss, Donghwa Kim, Eric M. Lewandowski, Yu Chen, and Stephen B. Liggett
Driving Forces of Liquid–Liquid Phase Separation in Biological Systems, Boris Y. Zaslavsky, Luisa A. Ferreira, and Vladimir N. Uversky
Cwp22, a Novel Peptidoglycan Cross-linking Enzyme, Plays Pleiotropic Roles in Clostridioides Difficile, Duolong Zhu, Jessica Bullock, Yongqun He, and Xingmin Sun
Submissions from 2018
Chemical Modifications of Insulin: Finding a Compromise Between Stability and Pharmaceutical Performance, Mohsen Akbarian, Younes Ghasemi, Vladimir N. Uversky, and Reza Yousefi
Structure–Function Relationships in the Oligomeric NADPH-Dependent Assimilatory Sulfite Reductase, Isabel Askenasy, Daniel T. Murray, Rachel M. Andrews, Vladimir N. Uversky, Huan He, and M. Elizabeth Stroupe
Neurodegenerative Diseases as Protein Folding Disorders, Jeremy D. Baker, Jack M. Webster, Lindsey B. Shelton, John Koren III, Vladimir N. Uversky, Laura J. Blair, and Chad A. Dickey
Born This Way: Using Intrinsic Disorder to Map the Connections Between SLITRKs, TSHR, and Male Sexual Orientation, Tara Basavanhally, Renée Fonseca, and Vladimir N. Uversky
Not All AMLETs Are Made Equal: Complexes of Cow and Camel Α-lactalbumin with Oleic Acid Show Different Structure and Stability, Leonid Breydo, Hussein A. Almehdar, Esmail M. El-Fakharany, Elrashdy M. Redwan, and Vladimir N. Uversky
Insights into the Molecular Mechanisms of Alzheimer’s and Parkinson’s Diseases with Molecular Simulations: Understanding the Roles of Artificial and Pathological Missense Mutations in Intrinsically Disordered Proteins Related to Pathology, Orkid Coskuner-Weber and Vladimir N. Uversky
Intrinsically Disordered Proteome of Human Membrane-Less Organelles, April L. Darling, Yun Liu, Christopher J. Oldfield, and Vladimir N. Uversky
Intrinsic Disorder and Posttranslational Modifications: The Darker Side of the Biological Dark Matter, April L. Darling and Vladimir N. Uversky
On the Relationship Between the Conserved ‘black’ and ‘gray’ Structural Clusters and Intrinsic Disorder in Parvalbumins, Eugenia I. Deryusheva, Alexander I. Denesyuk, Konstantin Denessiouk, Vladimir N. Uversky, Sergei E. Permyakov, and Eugene A. Permyakov
Trifunctional High-Throughput Screen Identifies Promising Scaffold To Inhibit Grp94 and Treat Myocilin-Associated Glaucoma, Dustin J. E. Huard, Vincent M. Crowley, Yuhong Du, Ricardo A. Cordova, Zheying Sun, Moya O. Tomlin, Chad A. Dickey, John Koren, Laura Blair, Haian Fu, Brian S. J. Blagg, and Raquel L. Lieberman
Virucidal Activity of Cell-penetrating Peptides of Viral Origin, Nawal Abd El-Baky, Vladimir N. Uversky, and Elrashdy M. Redwan
The Use of Human, Bovine, and Camel Milk Albumins in Anticancer Complexes with Oleic Acid, Esmail M. El-Fakharany, Marwa M. Abu-Serie, Ekaterina A. Litus, Sergei E. Permyakov, Eugene A. Permyakov, Vladimir N. Uversky, and Elrashdy M. Redwan
Structural Impact of Phosphorylation and Dielectric Constant Variation on Synaptotagmin’s IDR, Michael E. Fealey, Benjamin P. Binder, Vladimir N. Uversky, Anne Hinderliter, and David D. Thomas
Modified Binodal Model Describes Phase Separation in Aqueous Two-phase Systems in Terms of the Effects of Phase-forming Components on the Solvent Features of Water, L.A. Ferreira, Vladimir N. Uversky, and B.Y. Zaslavsky
Effect of Human Heat Shock Protein HspB6 on the Solvent Features of Water in Aqueous Solutions, Luisa A. Ferreira, Nikolai B. Gusev, Vladimir N. Uversky, and Boris Y. Zaslavsky
Phase Equilibria, Solvent Properties, and Protein Partitioning in Aqueous Polyethylene Glycol-600-trimethylamine N-oxide and Polyethylene Glycol-600-choline Chloride Two-phase Systems, Luisa A. Ferreira, Vladimir N. Uversky, and Boris Y. Zaslavsky
Effect of an Intrinsically Disordered Plant Stress Protein on the Properties of Water, Luisa A. Ferreira, Alicyia Walczyk Mooradally, Boris Zaslavsky, Vladimir N. Uversky, and Steffen P. Graether
Elucidating Feed‑forward Apoptosis Signatures in Breast Cancer Datasets: Higher FOS Expression Associated with a Better Outcome, Diana A. Fisler, Dhiraj Sikaria, John M. Yavorski, Yaping N. Tu, and George Blanck
Intrinsically Disordered Proteins in Crowded Milieu: When Chaos Prevails Within the Cellular Gumbo, Alexander V. Fonin, April L. Darling, Irina M. Kuznetsova, Konstantin K. Turoverov, and Vladimir N. Uversky
Oxidative Stress Induces Club Cell Proliferation and Pulmonary Fibrosis in Atp8b1 Mutant Mice, Jutaro Fukumoto, Joseph Leung, Ruan Cox Jr, Alexander Czachor, Prasanna Tamarapu Parthasarathy, Venu Lagishetty, Maria Mandry, Nima Hosseinian, Priyanshi Patel, Brittany Perry, Mason T. Breitzig, Matthew Alleyn, Athena Failla, Young Cho, Andrew J. Cooke, Lakshmi Galam, Ramani Soundararajan, Nirmal Sharma, Richard F. Lockey, and Narasaiah Kolliputi
Recombinant Fusion Protein Joining E Protein Domain III of Tick-Borne Encephalitis Virus and HSP70 of Yersinia pseudotuberculosis as an Antigen for the TI-complexes, Vasily Golotin, Nina M. Sanina, Ludmila Davydova, Natalia Chopenko, Andrey Mazeika, Manuel Roig, Valery L. Shnyrov, Vladimir N. Uversky, and Eduard Kostetsky
Arrestins: Structural Disorder Creates Rich Functionality, Vsevolod V. Gurevich, Eugenia V. Gurevich, and Vladimir N. Uversky
Taxonomic Landscape of the Dark Proteomes: Whole-Proteome Scale Interplay Between Structural Darkness, Intrinsic Disorder, and Crystallization Propensity, Gang Hu, Kui Wang, Jiangning Song, Vladimir N. Uversky, and Lukasz Kurgan
Potential Functions of LEA Proteins from the Brine Shrimp Artemia Franciscana – Anhydrobiosis Meets Bioinformatics, Brett Janis, Vladimir N. Uversky, and Michael A. Menze
Intrinsically Disordered Proteins and the Janus Challenge, Prakash Kulkarni and Vladimir N. Uversky
Intrinsically Disordered Proteins: The Dark Horse of the Dark Proteome, Prakash Kulkarni and Vladimir N. Uversky
Characterization of the Virulence of a Non-RT027, Non-RT078 and Binary Toxin-positive Clostridium Difficile Strain Associated with Severe Diarhea, Chunhui Li, Céline Harmanus, Duolong Zhu, Xiujuan Meng, Shaohui Wang, Juping Duan, Sidi Liu, Chenchao Fu, Pengcheng Zhou, Ruisi Liu, Anhua Wu, Ed J. Kuijper, Wiep Klaas Smits, Lei Fu, and Xingmin Sun
Intrinsically Disordered Regions in Serum Albumin: What Are They For?, Ekaterina A. Litus, Sergei E. Permyakov, Vladimir N. Uversky, and Eugene A. Permyakov
Functionally Aberrant Mutant KCNQ1 With Intermediate Heterozygous and Homozygous Phenotypes, Zhenning Liu, Renjian Zheng, Michael J. Grushko, Vladimir N. Uversky, and Thomas V. McDonald
A Statistical Approach to Detect Intrinsically Disordered Proteins Associated with Uterine Leiomyoma, Ujjwal Maulik, Vladimir N. Uversky, and Sagnik Sen
Dissecting Physical Structure of Calreticulin, an Intrinsically Disordered Ca2+-buffering Chaperone from Endoplasmic Reticulum, Anna Rita Migliaccio and Vladimir N. Uversky
Molecular Recognition Features in Zika Virus Proteome, Pushpendra Mani Mishra, Vladimir N. Uversky, and Rajanish Giri
Anti-Correlation Between the Dynamics of the Active Site Loop and C-Terminal Tail in Relation to the Homodimer Asymmetry of the Mouse Erythroid 5-Aminolevulinate Synthase, Insung Na, Dominique Catena, Min J. Kong, Gloria C. Ferreira, and Vladimir N. Uversky
Molecular Dynamics Analysis of the Structural and Dynamic Properties of the Functionally Enhanced Hepta-variant of Mouse 5-aminolevulinate Synthase, Insung Na, Shelly DeForte, Bosko M. Stojanovski, Gloria C. Ferreira, and Vladimir N. Uversky
Predicting Functions of Disordered Proteins with MoRFpred, Christopher J. Oldfield, Vladimir N. Uversky, and Lukasz Kurgan
Flexibility of the Sec13/31 Cage is Influenced by the Sec31 C-terminal Disordered Domain, Mohammadreza Paraan, Nilakshee Bhattacharya, Vladimir N. Uversky, and Scott M. Stagg
Alpha-synuclein Inhibits Snx3–retromer-mediated Retrograde Recycling of Iron Transporters in S. cerevisiae and C. elegans Models of Parkinson’s Disease, Dhaval Patel, Chuan Xu, Sureshbabu Nagarajan, Zhengchang Liu, Wayne O. Hemphill, Runhua Shi, Vladimir N. Uversky, Guy A. Caldwell, Kim A. Caldwell, and Stephan N. Witt
Design, Synthesis, and Characterization of a Fluorescence Polarization Pan-BET Bromodomain Probe, Carolyn N. Paulson, Xianghong Guan, Alex M. Ayoub, Alice Chan, Rezaul M. Karim, William C. K. Pomerantz, Ernst Schonbrunn, Gunda I. Georg, and Jon E. Hawkinson
Comprehensive Analysis of the Roles of ‘black’ and ‘gray’ Clusters in Structure and Function of Rat Β-parvalbumin, Sergei E. Permyakov, Alisa A. Vologzhannikova, Polina A. Khorn, Marina P. Shevelyova, Alexei S. Kazakov, Victor I. Emelyanenko, Alexander I. Denesyuk, Konstantin Denessiouk, Vladimir N. Uversky, and Eugene A. Permyakov
On the Regularities of the Polar Profiles of Proteins Related to Ebola Virus Infection and Their Functional Domains, Carlos Polanco, José Lino Samaniego Mendoza, Thomas Buhse, Vladimir N. Uversky, Ingrid Paola Bañuelos Chao, Marcela Angola Bañuelos Cedano, Fernando Michel Tavera, Daniel Michel Tavera, Manuel Falconi, and Abelardo Vela Ponce de León
Adenylyl Cyclase 6 is Required for Maintaining Acid–base Homeostasis, Søren Brandt Poulsen, Caralina Marin De Evsikova, Sathish Kumar Murali, Jeppe Praetorius, Yijuang Chern, Robert A. Fenton, and Timo Rieg
Prediction of Disordered Regions and Their Roles in the Anti-pathogenic and Immunomodulatory Functions of Butyrophilins, Elrashdy M. Redwan, Ahmed M. Al-Hejin, Hussein A. Almehdar, Abdulrahman Elsaway, and Vladimir N. Uversky
Variability of Some Milk-Associated Genes and Proteins in Several Breeds of Saudi Arabian Camels, Elrashdy M. Redwan, Salah Korim, Amro Samra, Yasser Saad, Hussein A. Amhedar, and Vladimir N. Uversky
Disorder in Milk Proteins: Lactadherin Multifunctionality and Structure, Bassam H. Sabha, Faud Alzahrani, Hussein A. Almehdar, Vladimir N. Uversky, and Elrashdy M. Redwan
Immunogenicity and Protective Activity of a Chimeric Protein Based on the Domain III of the Tick-Borne Encephalitis Virus E Protein and the OmpF Porin of Yersinia pseudotuberculosis Incorporated into the TI-complex, Nina M. Sanina, Natalia Chopenko, Andrey Mazeika, Ludmila Davydova, Galina Leonova, Anna Stenkova, Vladimir N. Uversky, and Eduard Kostetsky
Elucidating the Inhibitory Potential of Designed Peptides Against Amyloid Fibrillation and Amyloid Associated Cytotoxicity, Mohammad K. Siddiqi, Parvez Alam, Tabish Iqbal, Nabeela Majid, Sadia Malik, Saima Nusrat, Aftab Alam, Mohd R. Ajmal, Vladimir N. Uversky, and Rizwan H. Khan
Understanding the Interactability of Chikungunya Virus Proteins via Molecular Recognition Feature Analysis, Ankur Singh, Ankur Kumar, Vladimir N. Uversky, and Rajanish Giri
Deciphering the Dark Proteome of Chikungunya Virus, Ankur Singh, Ankur Kumar, Rakhi Yadav, Vladimir N. Uversky, and Rajanish Giri
In Silico Evaluation of the Resistance of the T790M Variant of Epidermal Growth Factor Receptor Kinase to Cancer Drug Erlotinib, Inderpal Singh, Shashank Singh, Vijeshwar Verma, Vladimir N. Uversky, and Ratna Chandra
Dissection of the Deep-blue Autofluorescence Changes Accompanying Amyloid Fibrillation, Tatiana N. Tikhonova, Nataliya R. Rovnyagina, Alexander Ya Zherebker, Nikolai N. Sluchanko, Anna A. Rubekina, Anton S. Orekhov, Eugene N. Nikolaev, Victor V. Fadeev, Vladimir N. Uversky, and Evgeny A. Shirshin
Bringing Darkness to Light: Intrinsic Disorder as a Means to Dig into the Dark Proteome, Vladimir N. Uversky
Conserved Functional Dynamics: I Like to Move It, Move It!, Vladimir N. Uversky
Intrinsic Disorder, Protein–Protein Interactions, and Disease, Vladimir N. Uversky
High-level Intrinsic Disorder Explains the Universality of CLIP Binding to Diverse MHC Class II Variants, Vladimir N. Uversky, Yaping N. Tu, Onyekachi Nwogu, Shanitra N. Butler, Michael Ramsamooj, and George Blanck
The Solvent Side of Proteinaceous Membrane-less Organelles in Light of Aqueous Two-phase Systems, Boris Y. Zaslavsky, Luisa A. Ferreira, April L. Darling, and Vladimir N. Uversky
In Aqua Veritas: The Indispensable Yet Mostly Ignored Role of Water in Phase Separation and Membrane-less Organelles, Boris Y. Zaslavsky and Vladimir N. Uversky
Submissions from 2017
In Vitro Exploration of the Anti-hcv Potential of the Synthetic Spacer Peptides Derived from Human, Bovine, and Camel Lactoferrins, Abdulgader H. Albar, Esmail M. El-Fakharany, Hussein A. Almehdar, Vladimir N. Uversky, and Elrashdy M. Redwan
Human Cyclophilin 40 Unravels Neurotoxic Amyloids, Jeremy D. Baker, Lindsey B. Shelton, Dali Zheng, Filippo Favretto, Bryce A. Nordhues, April Darling, Leia E. Sullivan, Zheying Sun, Parth K. Solanki, Mackenzie D. Martin, Amirthaa Suntharalingam, Jonathan J. Sabbagh, Stefan Becker, Eckhard Mandelkow, Vladimir N. Uversky, Markus Zweckstetter, Chad A. Dickey, John Koren III, and Laura J. Blair
Effects of Intrinsic and Extrinsic Factors on Aggregation of Physiologically Important Intrinsically Disordered Proteins, L. Breydo, J. M. Redington, and Vladimir N. Uversky
BMP-2 and BMP-9 Binding Specificities with ALK-3 in Aqueous Solution with Dynamics, Orkid Coskuner and Vladimir N. Uversky
Tyrosine Regulates β-sheet Structure Formation in Amyloid-β42: A New Clustering Algorithm for Disordered Proteins, Orkid Coskuner and Vladimir N. Uversky
Intrinsic Disorder in Proteins with Pathogenic Repeat Expansions, April L. Darling and Vladimir N. Uversky
Sertoli Cells Loaded with Doxorubicin in Lipid Micelles Reduced Tumor Burden and Dox-Induced Toxicity, Mahasweta Das, Mark Howell, Elspeth A. Foran, Rohit Iyre, Shyam S. Mohapatra, and Subhra Mohapatra
Not an Exception to the Rule: the Functional Significance of Intrinsically Disordered Protein Regions in Enzymes, Shelly DeForte and Vladimir N. Uversky
Quarterly Intrinsic Disorder Digest (April–May–June, 2014), Shelly DeForte and Vladimir N. Uversky
Quarterly Intrinsic Disorder Digest (April–May–June, 2014), Shelly DeForte and Vladimir N. Uversky
A Comprehensive Survey of the Roles of Highly Disordered Proteins in Type 2 Diabetes, Zhihua Du and Vladimir N. Uversky
Functional Roles of Intrinsic Disorder in CRISPR-associated Protein Cas9, Zhihua Du and Vladimir N. Uversky
Comparative Analysis of the Antiviral Activity of Camel, Bovine, and Human Lactoperoxidases Against Herpes Simplex Virus Type 1, Esmail M. El-Fakharany, Vladimir N. Uversky, and Elrashdy M. Redwan
The Calreticulin Control of Human Stress Erythropoiesis is Impaired by JAK2V617F in Polycythemia Vera, Mario Falchi, Lilian Varricchio, Fabrizio Martelli, Manuela Marra, Orietta Picconi, Agostino Tafuri, Gabriella Girelli, Vladimir N. Uversky, and Anna Rita Migliaccio
Role of Solvent Properties of Water in Crowding Effects Induced by Macromolecular Agents and Osmolytes, L. A. Ferreira, Vladimir N. Uversky, and B. Y. Zaslavsky
Effects of the Hofmeister Series of Sodium Salts on the Solvent Properties of Water, L. A. Ferreira, V. N. Uversky, and B. Y. Zaslavsky
Effects of Osmolytes on Solvent Features of Water in Aqueous Solutions, Luisa A. Ferreira, Leonid Breydo, Christian Reichardt, Vladimir N. Uversky, and Boris Y. Zaslavsky
Effects of Low Urea Concentrations on Protein-water Interactions, Luisa A. Ferreira, Olga I. Povarova, Olga V. Stepanenko, Anna I. Sulatskaya, Pedro P. Madeira, Irina M. Kuznetsova, Konstantin K. information, Vladimir N. information, and Boris Y. information
How to Manipulate Partition Behavior of Proteins in Aqueous Two-phase Systems: Effect of Trimethylamine N-oxide (TMAO), Luisa A. Ferreira, Zhonghua Wu, Lukasz Kurgan, Vladimir N. Uversky, and Boris Y. Zaslavsky
