Specific Cytokines of Interleukin-6 Family Interact with S100 Proteins
Document Type
Article
Publication Date
2022
Digital Object Identifier (DOI)
https://doi.org/10.1016/j.ceca.2021.102520
Abstract
Cytokines of interleukin-6 (IL-6) family are important signaling proteins involved in various physiological and pathological processes. Earlier, we described interactions between IL-11 and S100P/B proteins from the family of S100 proteins engaged in the pathogenesis of numerous diseases. We probed here interactions between seven IL-6 family cytokines (IL-6, IL-11, OSM, LIF, CNTF, CT-1, and CLCF1) and fourteen S100 proteins (S100A1/A4/A6/A7/A8/A9/A10/A11/A12/A13/A14/A15/B/P). Surface plasmon resonance spectroscopy revealed formation of calcium-dependent complexes between IL-11, OSM, CNTF, CT-1, and CLCF1 and distinct subsets of S100A1/A6/B/P proteins with equilibrium dissociation constants of 19 nM – 12 µM. The existence of a network of interactions between Ca2+-loaded S100 proteins and IL-6 family cytokines suggest regulation of these cytokines by the extracellular forms of S100 proteins.
Was this content written or created while at USF?
Yes
Citation / Publisher Attribution
Cell Calcium, v. 101, art. 102520
Scholar Commons Citation
Kazakov, Alexey S.; Sokolov, Andrey S.; Permyakova, Maria E.; Litus, Ekaterina A.; Uversky, Vladimir N.; Permyakov, Eugene A.; and Permyakov, Sergei E., "Specific Cytokines of Interleukin-6 Family Interact with S100 Proteins" (2022). Molecular Medicine Faculty Publications. 1021.
https://digitalcommons.usf.edu/mme_facpub/1021
