Co-opting Disorder Into Order: Intrinsically Disordered Proteins and the Early Evolution of Complex Multicellularity
Document Type
Article
Publication Date
2022
Keywords
Intrinsically Disordered Proteins, Multicellularity, Volvox Carteri, Chlamydomonas Reinhardtii, Protein Interaction Networks, Rega Protein, Self-organization, Complex Systems
Digital Object Identifier (DOI)
https://doi.org/10.1016/j.ijbiomac.2021.12.182
Abstract
Intrinsically disordered proteins (IDPs) are proteins that lack rigid structures yet play important roles in myriad biological phenomena. A distinguishing feature of IDPs is that they often mediate specific biological outcomes via multivalent weak cooperative interactions with multiple partners. Here, we show that several proteins specifically associated with processes that were key in the evolution of complex multicellularity in the lineage leading to the multicellular green alga Volvox carteri are IDPs. We suggest that, by rewiring cellular protein interaction networks, IDPs facilitated the co-option of ancestral pathways for specialized multicellular functions, underscoring the importance of IDPs in the early evolution of complex multicellularity.
Was this content written or created while at USF?
Yes
Citation / Publisher Attribution
International Journal of Biological Macromolecules, v. 201, p. 29-36
Scholar Commons Citation
Kulkarni, Prakash; Behal, Amita; Mohanty, Pranab; and Mohanty, Atish, "Co-opting Disorder Into Order: Intrinsically Disordered Proteins and the Early Evolution of Complex Multicellularity" (2022). Molecular Medicine Faculty Publications. 985.
https://digitalcommons.usf.edu/mme_facpub/985
