The Various Facets of Protein Promiscuity: Not Just Broad Specificity of Proteins
Document Type
Book Chapter
Publication Date
2023
Keywords
BAG Proteins, Catalytic Promiscuity, Conformational Dynamics, Condition Promiscuity, Directed Evolution, Intrinsic Disorder, Protein Engineering, Protein Evolution, Protein–protein Interactions, Rubisco, Substrate Ambiguity, Signal Transduction, Synuclein
Digital Object Identifier (DOI)
https://doi.org/10.1016/B978-0-323-99533-7.00009-1
Abstract
Biologically active proteins have broad specificity in classical enzymology. Protein promiscuity goes far beyond that, as it makes many of their molecular recognitions quite nonspecific. Enzyme promiscuity is exemplified by catalytic promiscuity, condition promiscuity, and substrate ambiguity. It is typically mediated by protein plasticity. On the other hand, promiscuity in protein–protein interactions shown by a very large number of regulatory proteins relies mostly on intrinsic disorder in at least one of the partners.
Was this content written or created while at USF?
Yes
Citation / Publisher Attribution
The Various Facets of Protein Promiscuity: Not Just Broad Specificity of Proteins, in M. N. Gupta & V. N. Uversky (Eds.), Structure and Intrinsic Disorder in Enzymology, Academic Press, p. 241-277
Scholar Commons Citation
Gupta, Munishwar Nath and Uversky, Vladimir N., "The Various Facets of Protein Promiscuity: Not Just Broad Specificity of Proteins" (2023). Molecular Medicine Faculty Publications. 1119.
https://digitalcommons.usf.edu/mme_facpub/1119
