Intrinsically Disordered Regions in Serum Albumin: What Are They For?
Document Type
Article
Publication Date
2018
Keywords
Serum albumin, Ligand binding, Intrinsicaly disordered region
Digital Object Identifier (DOI)
https://doi.org/10.1007/s12013-017-0785-6
Abstract
Serum albumin is a major plasma protein in mammalian blood. The importance of this protein lies in its roles in both bioregulation and transport phenomena. Serum albumin binds various metal ions and participates in the transport and storage of fatty acids, bilirubin, steroids amino acids, and many other ligands, usually with regions of hydrophobic surface. Although the primary role of serum albumin is to transport various ligand, its versatile binding capacities and high concentration mean that it can assume a number of additional functions. The major goal of this article is to show how intrinsic disorder is encoded in the amino acid sequence of serum albumin, and how intrinsic disorder is related to functions of this important serum protein.
Was this content written or created while at USF?
Yes
Citation / Publisher Attribution
Cell Biochemistry and Biophysics, v. 76, p. 39-57
Scholar Commons Citation
Litus, Ekaterina A.; Permyakov, Sergei E.; Uversky, Vladimir N.; and Permyakov, Eugene A., "Intrinsically Disordered Regions in Serum Albumin: What Are They For?" (2018). Molecular Medicine Faculty Publications. 237.
https://digitalcommons.usf.edu/mme_facpub/237
