Stochasticity of Biological Soft Matter: Emerging Concepts in Intrinsically Disordered Proteins and Biological Phase Separation
Document Type
Article
Publication Date
2019
Keywords
biological soft matter, liquid-liquid phase transition, edge of chaos, emergent behavior
Digital Object Identifier (DOI)
https://doi.org/10.1016/j.tibs.2019.03.005
Abstract
At the turn of this century, cardinal changes took place in the perceptions of the structure and function of proteins, as well as in the organizational principles of membrane-less organelles. As a result, the model of the organization of living matter is changing to one described by highly dynamic biological soft matter positioned at the edge of chaos. Intrinsically disordered proteins (IDPs) and membrane-less organelles are key examples of this new outlook and may represent a critical foundation of life, defining its complexity and the evolution of living things.
Was this content written or created while at USF?
Yes
Citation / Publisher Attribution
Trends in Biochemical Sciences, v. 44, issue 8, p. 716-728
Scholar Commons Citation
Turoverov, Konstantin K.; Kuznetsova, Irina M.; Fonin, Alexander V.; Darling, April L.; Zaslavsky, Boris Y.; and Uversky, Vladimir N., "Stochasticity of Biological Soft Matter: Emerging Concepts in Intrinsically Disordered Proteins and Biological Phase Separation" (2019). Molecular Medicine Faculty Publications. 146.
https://digitalcommons.usf.edu/mme_facpub/146
