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Submissions from 2018

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Daily Zeaxanthin Supplementation Prevents Atrophy of the Retinal Pigment Epithelium (RPE) in a Mouse Model of Mitochondrial Oxidative Stress, Manas R. Biswal, Bradley D. Justis, Pingyang Han, Hong Li, Dennis Gierhart, Cheryl K. Dorey, and Alfred S. Lewin

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Physiological Role of Kvβ2 (AKR6) in Murine Skeletal Muscle Growth and Regulation, K. C. Chapalamadugu, Jared Tur, S. L. Badole, R. C. Kukreja, M. Brotto, and S. M. Tippraju

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Expanding the Scope of Universal Design: Implications for Gender Identity and Sexual Orientation, Ellyn Couillard and Jeanne L. Higbee

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Toward the Synthesis and Improved Biopotential of an N-methylated Analog of a Proline-Rich Cyclic Tetrapeptide from Marine Bacteria, Rajiv Dahiya, Suresh Kumar, Suhkbir Lal Khokra, Sheeba Varghese Gupta, Vijaykumar B. Sutariya, Deepak Bhatia, Ajay Sharma, Shamjeet Singh, and Sandeep Maharaj

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Assessment of Cardiovascular Function and Microvascular Permeability in a Conscious Rat Model of Alcohol Intoxication Combined with Hemorrhagic Shock and Resuscitation, Travis M. Doggett, Jared J. Tur, Natascha Alves, Sarah Y. Yuan, Srinicas M. Tipparaju, and Jerome W. Breslin

Development and In Vitro Release of Isoniazid and Rifampicin-Loaded Bovine Serum Albumin Nanoparticles, Zhaohui Ge, Rong Ma, Guangxian Xu, Zhen Cheng, Dangfeng Zhang, Qian Wang, Long Hei, and Wei Ma

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Salts of Therapeutic Agents: Chemical, Physicochemical, and Biological Considerations, Deepak Gupta, Deepak Bhatia, Vivek Dave, Vijaykumar B. Sutariya, and Sheeba Varghese Gupta

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Analyzing the Genes Related to Nicotine Addiction or Schizophrenia via a Pathway and Network Based Approach, Ying Hu, Zhonghai Fang, Yichen Yang, Dekai Rohlsen-Neal, Feng Cheng, and Ju Wang

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Requisite Endothelial Reactivation and Effective siRNA Nanoparticle Targeting of Etv2/Er71 in Tumor Angiogenesis, Ashraf Ul Kabir, Tae-Jin Lee, Hua Pan, Jeffrey C. Berry, Karen Krchma, Jun Wu, Fang Liu, Samuel A. Wickline, and Qingyu Zhou

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Aflibercept Nanoformulation Inhibits VEGF Expression in Ocular In Vitro Model: A Preliminary Report, Shannon J. Kelly, Anjali Hirani, Vishal Shahidadpury, Aum Solanki, Kathleen Halasz, Sheeba Varghese Gupta, Brian Madow, and Vijaykumar B. Sutariya

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Fibroblast Growth Factor23 is associated with Axonal Integrity and Neural Network Architecture in the Human Frontal Lobes, Barbara K. Marebwa, Robert J. Adams, Gayenell S. Magwood, Mark S. Kindy, Janina Wilmskoetter, Myles Wolf, and Leonardo Bonihla

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Implication of the Kallikrein-Kinin System in Neurological Disorders: Quest for Potential Biomarkers and Mechanisms, Amaly Nokkari, Hadi Abou-El-Hassan, Yehia Mechref, Stefania Mondello, Mark S. Kindy, Ayad A. Jaffa, and Firas Kobeissy

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Role of Nutritional Factors in Pathogenesis of Cancer, Anita Patel, Yashwant Pathak, Jayvadan Patel, and Vijaykumar B. Sutariya

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Polypharmacology or Promiscuity? Structural Interactions of Resveratrol With Its Bandwagon of Targets, Uzma Saqib, Tanya T. Kelley, Siva K. Panguluri, Dongfang Liu, Rajkumar Savai, Mirza S. Baig, and Stephan C. Schürer

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GM604 Regulates Developmental Neurogenesis Pathways and the Expression of Genes Associated with Amyotrophic Lateral Sclerosis, William R. Swindell, Krzysztof Bojanowski, Mark S. Kindy, Raymond M. W. Chau, and Dorothy Ko

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Organellar Genome Assembly Methods and Comparative Analysis of Horticultural Plants, Xueling Wang, Feng Cheng, Dekai Rohlsen, Changwei Bi, Chunyan Wang, Yiqing Xu, Suyun Wei, Qiaolin Ye, Tongming Yin, and Ning Ye

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Implementation of Standardized Clinical Processes for TPMT Testing in a Diverse Multidisciplinary Population: Challenges and Lessons Learned, Kristin W. Weitzel, D. M. Smith, Amanda R. Elsey, Benjamin Q. Duong, Benjamin Burkley, Michael Clare-Salzler, Yan Gong, Tara A. Higgins, Benjamin Kong, and Teresa T. Vo

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A Mechanistic Study on Reduced Toxicity of Irinotecan by Coadministered Thalidomide, a Tumor Necrosis Factor-α Inhibitor, Xiao-Xia Yang, Ze-Ping Hu, An-Long Xu, Wei Duan, Yi-Zhun Zhu, Min Huang, Fwu-Shan Sheu, Qiang Zhang, Jin-Song Bian, Eli Chan, Xiaotian Li, Jian-Cheng Wang, and Shufeng Zhou

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Impact of Nutrition on Inflammation, Tauopathy, and Behavioral Outcomes from Chronic Traumatic Encephalopathy, Jin Yu, Hong Zhu, Saeid Taheri, William Mondy, Stephen Perry, and Mark S. Kindy

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The Effect of Diet on Improved Endurance in Male C57BL/6 Mice, Jin Yu, Hong Zhu, Saeid Taheri, Stephen Perry, and Mark S. Kindy

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A Quantitative Proteomic Response of Hepatocellular Carcinoma Hep3B Cells to Danusertib, a Pan-Aurora Kinase Inhibitor, Quiaohua Zhu, Xinfa Yu, Zhi-Wei Zhou, Meihua Luo, Chengyu Zhou, Zhi-Xu He, Yong Chen, and Shu-Feng Zhou

Submissions from 2013

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The Effect of Somatostatin, Ulinastatin and Salvia Miltiorrhiza on Severe Acute Pancreatitis Treatment, Guiliang Wang, Jianbo Wen, Ping Wen, Rhonda R. Wilbur, Shufeng Zhou, and Xianzhong Xiao

Submissions from 2012

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Ligand- and Protein-Based Modeling Studies of the Inhibitors of Human Cytochrome P450 2D6 and a Virtual Screening for Potential Inhibitors from the Chinese Herbal Medicine, Scutellaria Baicalensis (Huangqin,Baikal Skullcap), Sui-Lin Mo, Wei-Feng Liu, Yuling Chen, Hai-Bin Luo, Lai-Bao Sun, Xiao-Wu Chen, Zhi-Wei Zhou, Kevin B. Sneed, Chun Guang Li, Yao-Min Du, Jun Liang, and Shu-Feng Zhou

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Cell Therapy: A Safe and Efficacious Therapeutic Treatment for Alzheimer’s Disease in APP+PS1 Mice, Neel R. Nabar, Fang Yuan, Xiaoyang Lin, Li Wang, Ge Bai, Jonathan Mayl, Yaqiong Li, Shu-Feng Zhou, Jinhuan Wang, Jianfeng Cai, and Chuanhai Cao

Submissions from 2007

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Simple Reversed-Phase Liquid Chromatographic Assay for Simultaneous Quantification of Free Mycophenolic Acid and its Glucuronide Metabolite in Human Plasma, Wai-Ping Yau, Anantharaman Vathsala, Huei-Xin Lou, Shu Feng Zhou, and Eli Chan

Submissions from 2006

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St. John's Wort Attenuates Irinotecan-induced Diarrhea via Down-regulation of Intestinal Pro-inflammatory Cytokines and Inhibition of Intestinal Epithelial Apoptosis, Ze-Ping Hu, Xiao-Xia Yang, Sui Yung Chan, An-Long Xu, Wei Duan, Yi-Zhun Zhu, Fwu-Shan Sheu, Urs Alex Boelsterli, Eli Chan, Qiang Zhang, Jian-Cheng Wang, Pui Lai Rachel Ee, Hwee Ling Koh, and Min Huang

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Detection of Aristolochic Acid I, Tetrandrine and Fangchinoline in Medicinal Plants by High Performance Liquid Chromatography and Liquid Chromatography/Mass Spectrometry, H.L. Koh, H. Wang, Shufeng Zhou, Eli Chan, and S.O. Woo

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Pharmacokinetics of Recombinant Human Endostatin in Rats, Xiao-Xia Yang, Zen-Ping Hu, Eli Chan, Wei Duan, and Shufeng Zhou

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Monitoring Drug-Protein Interaction, Xiao-Xia Yang, Ze-Ping Hu, Sui Yung Chan, and Shufeng Zhou

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Drug-Herb Interactions: Eliminating Toxicity with Hard Drug Design, Xiao-Xia Yang, Ze-Ping Hu, Wei Duan, Yi-Zhun Zhu, and Shufeng Zhou

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The Last 10 Amino Acid Residues Beyond the Hydrophobic Motif are Critical for the Catalytic Competence and Function of Protein Kinase Cα, Sui Sum Yeong, Yimin Zhu, Derek Smith, Chandra Verma, Wee Guan Lim, Bee Jen Tan, Qiu Tian Li, Nam Sang Cheung, Minnie Cai, Yi-Zhun Zhu, Shu-Feng Zhou, Seng-Lai Tan, and Wei Duan

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Reversal of Resistance to Oxazaphosphorines, Jing Zhang, Quan Tian, Yi-Zhun Zhu, An-Long Xu, and Shufeng Zhou

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Clinical Pharmacogenomics of Thiopurine S-methyltransferase, Shufeng Zhou and Brink

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The Very C-Terminus of Protein Kinase Cɛ is Critical for the Full Catalytic Competence but its Hydrophobic Motif is Dispensable for the Interaction with 3-Phosphoinositide-Dependent Kinase-1, Yimin Zhu, Derek Smith, Chandra Verma, Wee Guan Lim, Bee Jen Tan, Jeffrey S. Armstrong, Shufeng Zhou, Eli Chan, Seng-Lai Tan, Yi-Zhun Zhu, Nam Sang Cheung, and Wei Duan

Submissions from 2005

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St. John’s Wort Modulates the Toxicities and Pharmacokinetics of CPT-11 (Irinotecan) in Rats, Zeping Hu, Xiaoxia Yang, Paul Chi-Liu Ho, Eli Chan, Sui Yung Chan, Congjian Xu, Xiaotian Li, Yi-Zhun Zhu, Wei Duan, Xiao Chen, Min Huang, Hongyuan Yang, and Shufeng Zhou

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Herb-Drug Interactions, Zeping Hu, Xiaoxia Yang, Paul Chi Lui Ho, Sui Yung Chan, Paul Wan Sia Heng, Eli Chan, Wei Duan, Hwee Ling Koh, and Shufeng Zhou

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Significant Intestinal Excretion, One Source of Variability in Pharmacokinetics of COL-3, a Chemically Modified Tetracycline, Jing Li, Shufeng Zhou, Hung Huynh, and Eli Chan

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Alteration of the Pharmacokinetics of COL-3, a Matrix Metalloproteinase Inhibitor, Due to Acute Gastrointestinal Toxicity of Doxorubicin, Jing Li, Shufeng Zhou, Hung Huynh, Wei Duan, and Eli Chan

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Inhibition of Human CYP1A2 Oxidation of 5,6-Dimethyl-Xanthenone-4-Acetic Acid by Acridines: a Molecular Modelling Study, James W. Paxton, Philip Kestell, Daniel Chiang, Shufeng Zhou, and David FV Lewis

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Human Multidrug Resistance Associated Protein 4 Confers Resistance to Camptothecins, Quan Tian, Jing Zhang, Theresa May Chin Tan, Eli Chan, Wei Duan, Sui Yung Chan, Urs Alex Boelsterli, Paul Chi-Lui Ho, Hongyuan Yang, Jin-Song Bian, Min Huang, Yi-Zhun Zhu, Weiping Xiong, Xiaotian Li, and Shufeng Zhou

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Novel Agents that Potentially Inhibit Irinotecan-Induced Diarrhea, Xiaoxia Yang, Zeping Hu, Sui Y. Chan, Eli Chan, Boon Cher Goh, Wei Duan, and Shufeng Zhou

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Simultaneous Determination of the Lactone and Carboxylate Forms of Irinotecan (CPT-11) and its Active Metabolite SN-38 by High-Performance Liquid Chromatography: Application to Plasma Pharmacokinetic Studies in the Rat, Xiaoxia Yang, Zeping Hu, Sui Yung Chan, Boon Cher Goh, Wei Duan, Eli Chan, and Shufeng Zhou

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Determination of Thalidomide by High Performance Liquid Chromatography: Plasma Pharmacokinetic Studies in the Rat, Xiaoxia Yang, Zeping Hu, Sui Yung Chan, Paul C. Ho, Eli Chan, Wei Duan, Boon Cher Goh, and Shufeng Zhou

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Insights into Oxazaphosphorine Resistance and Possible Approaches to its Circumvention, Jing Zhang, Quan Tian, Sui Yung Chan, Wei Duan, and Shufeng Zhou

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Metabolism and Transport of Oxazaphosphorines and the Clinical Implications, Jing Zhang, Quan Tian, Sui Yung Yung Chan, Shu Chuen Li, Shufeng Zhou, Wei Duan, and Yei-Zhun Zhu

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Effect of Coenzyme Q10 on Warfarin Hydroxylation in Rat and Human Liver Microsomes, Qingyu Zhou, Shufeng Zhou, and Eli Chan

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Effect of Omeprazole on the Hydroxylation of Warfarin Enantiomers in Human: In-Vitro Studies with Liver Microsomes and cDNA-Expressed Cytochrome P450 Isozymes, Qing Zhou, Shufeng Zhou, and Eli Chan

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Drug Bioactivation Covalent Binding to Target Proteins and Toxicity Relevance, Shufeng Zhou, Eli Chan, Wei Duan, Min Huang, and Yu-Zong Chen

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Transport of the Investigational Anti-Cancer Drug 5,6-Dimethylxanthenone-4-Acetic Acid and its Acyl Glucuronide by Human Intestinal Caco-2 Cells, Shufeng Zhou, Xia Feng, Philip Kestell, James W. Paxton, Bruce C. Baguley, and Eli Chan

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Prediction of Herb–Drug Metabolic Interactions: a Simulation Study, Shufeng Zhou, Min Huang, Anlong Xu, Hongyuan Yang, Wei Duan, and James W. Paxton

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Transport of Thalidomide by the Human Intestinal Caco-2 Monolayers, Shufeng Zhou, Yan Li, Phillip Kestell, Peter Schafer, Eli Chan, and James W. Paxton

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Mechanism-Based Inhibition of Cytochrome P450 3A4 by Therapeutic Drugs, Shufeng Zhou, Sui Yung Chan, Boon Cher Goh, Eli Chan, Wei Duan, Min Huang, and Howard L. McLeod

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The PKCα-D294G Mutant Found in Pituitary and Thyroid Tumors Fails to Transduce Extracellular Signals, Yimin Zhu, Qihan Dong, Bee Jen Tan, Wee Guan Lim, Shufeng Zhou, and Wei Duan

Submissions from 2004

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Therapeutic Drugs that Behave as Mechanism-Based Inhibitors of Cytochrome P450 3A4, Shufeng Zhou, Eli Chan, Lee Y. Lim, Urs A. Boelsterli, Shu Chuen Li, Jiancheng Wang, Qiang Zhang, Min Huang, and Anlong Xu

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Predicting Pharmacokinetic Herb-Drug Interactions, Shufeng Zhou, Eli Chan, Shu Chuen Li, Min Huang, Xiao Chen, Xiaotian Li, Qiang Zhang, and James W. Paxton

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Pharmacokinetic Interactions of Drugs with St John’s Wort, Shufeng Zhou, Eli Chan, Shen-Quan Pan, Min Huang, and Edmund Jon Deoon Lee

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Determination of the Investigational Anti-Cancer Drug 5,6-Dimethylxanthenone-4-Acetic Acid and its Acyl Glucuronide in Caco-2 Monolayers by Liquid Chromatography with Fluorescence Detection: Application to Transport Studies, Shufeng Zhou, Xia Feng, Philip Kestell, Bruce C. Baguley, and James W. Paxton

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Herbal Bioactivation: The Good, The Bad and The Ugly, Shufeng Zhou, Hwee-Ling Koh, Yihuai Gao, Zhi-yuan Gong, and Edmund Jon Deoon Lee

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Herbal Modulation of P‐Glycoprotein, Shufeng Zhou, Lee Yong Lim, and Balram Chowbay

Submissions from 2001

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Effects of Anticancer Drugs on the Metabolism of the Anticancer Drug 5,6-Dimethylxanthenone-4-Acetic (DMXAA) by Human Liver Microsomes, Shufeng Zhou, Rebecca Chin, Philip Kestell, Malcolm D. Tingle, and James W. Paxton

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A Difference between the Rat and Mouse in the Pharmacokinetic Interaction of 5,6-Dimethylxanthenone-4-Acetic Acid with Thalidomide, Shufeng Zhou, Philip Kestell, Malcolm D. Tingle, Lai-Ming Ching, and James W. Paxton