The Effect of Somatostatin, Ulinastatin and Salvia Miltiorrhiza on Severe Acute Pancreatitis Treatment
Document Type
Article
Publication Date
11-2013
Keywords
severe acute pancreatitis, somatostatin, ulinastatin, salvia miltiorrhiza
Digital Object Identifier (DOI)
https://doi.org/10.1097/MAJ.0b013e31827aa2bc
Abstract
Background: The aim of this study was to evaluate the efficacy of somatostatin, ulinastatin and Salvia miltiorrhiza for treatment of severe acute pancreatitis.
Methods: Three hundred six patients with severe acute pancreatitis were divided randomly into 5 groups: basic treatment, somatostatin, somatostatin + ulinastatin, somatostatin + S miltiorrhiza and somatostatin + ulinastatin + S miltiorrhiza. Amount of time for resolution of abdominal pain/distention, recovery to normal heart and respiratory rates, amylase and blood glucose levels, Acute Physiology and Chronic Health Evaluation II scores, and levels of tumor necrosis factor-α, interleukin (IL)-6, and IL-10 were analyzed and recorded for all 5 subgroups.
Results: Tumor necrosis factor-α and IL-6 levels on the fourth and seventh days, and Acute Physiology and Chronic Health Evaluation II scores on the seventh day after treatment showed significant decrease in the somatostatin, somatostatin + ulinastatin, somatostatin + S miltiorrhiza and somatostatin + ulinastatin + S miltiorrhiza subgroups compared with the basic treatment subgroup. IL-10 levels on the fourth and seventh days were significantly improved in the somatostatin + ulinastatin, somatostatin + S miltiorrhiza and somatostatin + ulinastatin + S miltiorrhiza subgroups compared with the basic treatment subgroup. The incidences of pancreatic sepsis, multiple organ dysfunction syndrome and mortality were lower in the somatostatin, somatostatin + ulinastatin, somatostatin + S miltiorrhiza and somatostatin + ulinastatin + S miltiorrhiza subgroups compared with the basic treatment subgroup.
Conclusions: Somatostatin is effective for the treatment of acute pancreatitis and both ulinastatin and S miltiorrhiza demonstrate improvement in therapeutic benefits.
Was this content written or created while at USF?
Yes
Citation / Publisher Attribution
The American Journal of the Medical Sciences, v. 346, issue 5, p. 371-376
Scholar Commons Citation
Wang, Guiliang; Wen, Jianbo; Wen, Ping; Wilbur, Rhonda R.; Zhou, Shufeng; and Xiao, Xianzhong, "The Effect of Somatostatin, Ulinastatin and Salvia Miltiorrhiza on Severe Acute Pancreatitis Treatment" (2013). Pharmacy Faculty Publications. 2.
https://digitalcommons.usf.edu/pharm_facpub/2
