The Effect of Somatostatin, Ulinastatin and Salvia Miltiorrhiza on Severe Acute Pancreatitis Treatment

Authors

Guiliang Wang, Nanfang Medical University
Jianbo Wen, Nanfang Medical University
Ping Wen, Nanfang Medical University
Rhonda R. Wilbur, University of South Florida
Shufeng Zhou, University of South FloridaFollow
Xianzhong Xiao, Central South University

Document Type

Article

Publication Date

11-2013

Keywords

severe acute pancreatitis, somatostatin, ulinastatin, salvia miltiorrhiza

Digital Object Identifier (DOI)

https://doi.org/10.1097/MAJ.0b013e31827aa2bc

Abstract

Background: The aim of this study was to evaluate the efficacy of somatostatin, ulinastatin and Salvia miltiorrhiza for treatment of severe acute pancreatitis.

Methods: Three hundred six patients with severe acute pancreatitis were divided randomly into 5 groups: basic treatment, somatostatin, somatostatin + ulinastatin, somatostatin + S miltiorrhiza and somatostatin + ulinastatin + S miltiorrhiza. Amount of time for resolution of abdominal pain/distention, recovery to normal heart and respiratory rates, amylase and blood glucose levels, Acute Physiology and Chronic Health Evaluation II scores, and levels of tumor necrosis factor-α, interleukin (IL)-6, and IL-10 were analyzed and recorded for all 5 subgroups.

Results: Tumor necrosis factor-α and IL-6 levels on the fourth and seventh days, and Acute Physiology and Chronic Health Evaluation II scores on the seventh day after treatment showed significant decrease in the somatostatin, somatostatin + ulinastatin, somatostatin + S miltiorrhiza and somatostatin + ulinastatin + S miltiorrhiza subgroups compared with the basic treatment subgroup. IL-10 levels on the fourth and seventh days were significantly improved in the somatostatin + ulinastatin, somatostatin + S miltiorrhiza and somatostatin + ulinastatin + S miltiorrhiza subgroups compared with the basic treatment subgroup. The incidences of pancreatic sepsis, multiple organ dysfunction syndrome and mortality were lower in the somatostatin, somatostatin + ulinastatin, somatostatin + S miltiorrhiza and somatostatin + ulinastatin + S miltiorrhiza subgroups compared with the basic treatment subgroup.

Conclusions: Somatostatin is effective for the treatment of acute pancreatitis and both ulinastatin and S miltiorrhiza demonstrate improvement in therapeutic benefits.

Was this content written or created while at USF?

Yes

Citation / Publisher Attribution

The American Journal of the Medical Sciences, v. 346, issue 5, p. 371-376

Scholar Commons Citation

Wang, Guiliang; Wen, Jianbo; Wen, Ping; Wilbur, Rhonda R.; Zhou, Shufeng; and Xiao, Xianzhong, "The Effect of Somatostatin, Ulinastatin and Salvia Miltiorrhiza on Severe Acute Pancreatitis Treatment" (2013). Pharmacy Faculty Publications. 2.
https://digitalcommons.usf.edu/pharm_facpub/2