Document Type
Article
Publication Date
2014
Keywords
miR-382, osteosarcoma growth, chemoresistance
Digital Object Identifier (DOI)
https://doi.org/10.18632/oncotarget.2418
Abstract
Dysregulation of miRNAs is involved in osteosarcoma (OS). Here, we demonstrate that miR-382 is decreased in specimens of OS patients with a poor chemoresponse compared to those with a good chemoresponse. In addition, our clinical data show that decreased miR-382 was associated with poor survival in OS patients. Overexpression of miR-382 inhibited cell growth and chemoresistance by targeting KLF12 and HIPK3, respectively. In contrast, inhibition of miR-382 or overexpression of target genes stimulated OS cell growth and chemoresistance both in vitro and in vivo. Taken together, these findings suggest that miR-382 is a tumor suppressor miRNA and induction of miR-382 is a potential strategy to inhibit OS progression.
Rights Information
This work is licensed under a Creative Commons Attribution 3.0 License.
Was this content written or created while at USF?
Yes
Citation / Publisher Attribution
Oncotarget, v. 5, issue 19, p. 9472-9483
Scholar Commons Citation
Xu, Meng; Jin, Hua; Xu, Cheng-Xiong; Sun, Bo; Mao, Zhi; Bi, Wen-Zhi; and Wang, Yan, "miR-382 Inhibits Tumor Growth and Enhance Chemosensitivity in Osteosarcoma" (2014). Pharmacy Faculty Publications. 83.
https://digitalcommons.usf.edu/pharm_facpub/83
