Document Type
Article
Publication Date
2015
Keywords
cancer, cancer stem cell, anti-cancer treatment, cancer stem cell marker, cancer stem cell model
Digital Object Identifier (DOI)
https://doi.org/10.18632/oncotarget.6176
Abstract
Although cancer stem cells have been well characterized in numerous malignancies, the fundamental characteristics of this group of cells, however, have been challenged by some recent observations: cancer stem cells may not necessary to be rare within tumors; cancer stem cells and non-cancer stem cells may undergo reversible phenotypic changes; and the cancer stem cells phenotype can vary substantially between patients. Here the current status and progresses of cancer stem cells theory is illustrated and via providing a panoramic view of cancer therapy, we addressed the recent controversies regarding the feasibility of cancer stem cells targeted anti-cancer therapy.
Rights Information
This work is licensed under a Creative Commons Attribution 3.0 License.
Was this content written or created while at USF?
Yes
Citation / Publisher Attribution
Oncotarget, v. 6, issue 42, p. 44191-44206
Scholar Commons Citation
Wang, Tao; Shigdar, Sarah; Gantier, Michael P.; Hou, Yingchun; Wang, Li; Li, Yong; Shamaileh, Hadi Al; Yin, Wang; Zhou, Shu-Feng; Zhao, Xinhan; and Duan, Wei, "Cancer Stem Cell Targeted Therapy: Progress Amid Controversies" (2015). Pharmacy Faculty Publications. 82.
https://digitalcommons.usf.edu/pharm_facpub/82
