Document Type
Article
Publication Date
2017
Keywords
miRNA-200c, c-Myc, PTEN, nasopharyngeal carcinoma
Digital Object Identifier (DOI)
https://doi.org/10.18632/oncotarget.14123
Abstract
The c-Myc transcription factor regulates a complex transcriptional program that leads to cellular transformation by targeting a large number of protein-encoding genes and non-coding RNAs. In this study, we show that a microRNA, miR-200c, is a novel c-Myc target that promotes cellular transformation and metastasis in nasopharyngeal carcinoma. MiR-200c achieves this oncogenic effect, at least in part, by targeting and inhibiting the tumor suppressor gene PTEN (phosphatase and tensin homolog), which is a key inhibitor of the AKT kinase signaling that promotes tumorigenesis in nasopharyngeal carcinoma. Our study thus identifies cMyc-miR-200c-PTEN-AKT as a functional module that promotes cellular transformation in nasopharyngeal carcinoma.
Rights Information
This work is licensed under a Creative Commons Attribution 3.0 License.
Was this content written or created while at USF?
Yes
Citation / Publisher Attribution
Oncotarget, v. 8, issue 3 p. 5206-5218
Scholar Commons Citation
Chen, Pan; Guo, Xiaofang; Zhang, Liming; Zhang, Wenling; Zhou, Qingyu; Tian, Zhi; Zheng, Ying; Liao, Qianjin; Wang, Heran; Li, Guiyuan; Huang, Jin; and Li, Xiayu, "MiR-200c is a cMyc-activated miRNA that Promotes Nasopharyngeal Carcinoma by Downregulating PTEN" (2017). Pharmacy Faculty Publications. 87.
https://digitalcommons.usf.edu/pharm_facpub/87
