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Submissions from 2020

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Metabolic Switching Is Impaired by Aging and Facilitated by Ketosis Independent of Glycogen, Abbi Hernandez, Leah Truckenbrod, Quinten Federico, Keila Campos, Brianna Moon, Nedi Ferekides, Meagan Hoppe, Dominic D’Agostino, and Sara Burke

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Ketone Bodies Attenuate Wasting in Models of Atrophy, Andrew P. Koutnik, Angela M. Poff, Nathan P. Ward, Janine M. DeBlasi, Maricel A. Soliven, Matthew A. Romero, Paul A. Roberson, Carl D. Fox, Michael D. Roberts, and Dominic P. D'Agostino

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Structural Determinants Mediating Tertiapin Block of Neuronal Kir3.2 Channels, Dharmeshkumar Patel, Serdar Kuyucak, and Craig A. Doupnik

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Effects of an Exogenous Ketone Supplement on Five‐Kilometer Running Performance, Philip J. Prins, Andrew P. Koutnik, Dominic P. D’Agostino, Christopher Q. Rogers, Jacob F. Seibert, Jillian A. Breckenridge, Daniel S. Jackson, Edward J. Ryan, Jeffrey D. Buxton, and Dana L. Ault

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Collagen XII Is a Regulator of Corneal Stroma Structure and Function, Mei Sun, Nabeel Zafrullah, Floriane Devaux, Chinda Hemmavanh, Sheila Adams, Noel M. Ziebarth, Manuel Koch, David E. Birk, and Edgar M. Espana

Submissions from 2019

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Impact of Repetitive Mild Traumatic Brain Injury on Behavioral and Hippocampal Deficits in a Mouse Model of Chronic Stress, Moustafa Algamal, Nicole Saltiel, Andrew J. Pearson, Bryan Ager, Ioana Burca, Benoit Mouzon, David M. Diamond, Michael Mullan, Joseph O. Ojo, and Fiona Crawford

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Sphingosine-1-phosphate Protects against Brain Microvascular Endothelial Junctional Protein Disorganization and Barrier Dysfunction Caused by Alcohol, Natascha G. Alves, Sarah Y. Yuan, and Jerome W. Breslin

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Chemokine (C-X-C Motif) Receptor 4 Regulates Lung Endothelial Barrier Permeability During Resuscitation from Hemorrhagic Shock, F. S. Babu, H. M. Laporte, S. P. Nassoiy, and M. Majetschak

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Reduced Myocyte Complex N-glycosylation Causes Dilated Cardiomyopathy, Andrew R. Ednie, Wei Deng, Kay-Pong Yip, and Eric S. Bennett

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Nociceptive Pulmonary-cardiac Reflexes Are Altered in the Spontaneously Hypertensive Rat, J. Shane Hooper, Katherine R. Stanford, Pierina A. Alencar, Natascha G. Alves, Jerome W. Breslin, Jay B. Dean, Kendall F. Morris, and Thomas E. Taylor-Clark

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Evidence of Functional Ryanodine Receptors in Rat Mesenteric Collecting Lymphatic Vessels, Michiko Jo, Andrea N. Trujillo, Ying Yang, and Jerome W. Breslin

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Exploring the Viability of Exogenous Ketones as Weight Loss Supplements, Angela Poff, Andrew Koutnik, Sara Moss, Sahith Mandala, and Dominic D'Agostino

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Knockout of NA+-Glucose Cotransporter SGLT1 Mitigates Diabetes-Induced Upregulation of Nitric Oxide Synthase NOS1 in the Macula Densa and Glomerular Hyperfiltration, Panai Song, Winnie Huang, Akira Onishi, Rohit Patel, Young Chul Kim, Charlotte van Ginkel, Yiling Fu, Brent Freeman, Hermann Koepsell, Scott Thomson, Ruisheng Liu, and Volker Vallon

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A Mouse Model of Renal Ischemia-reperfusion Injury Solely Induced by Cold Ischemia, Jin Wei, Yingliang Wang, Jie Zhang, Lei Wang, Liying Fu, Byeong J. Cha, Jacentha Buggs, and Ruisheng Liu

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High-Protein Diet–Induced Glomerular Hyperfiltration Is Dependent on Neuronal Nitric Oxide Synthase β in the Macula Densa via Tubuloglomerular Feedback Response, Jin Wei, Jie Zhang, Shan Jiang, Lei Wang, A. Erik G. Persson, and Ruisheng Liu

Submissions from 2018

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Biased TAS2R Bronchodilators Inhibit Airway Smooth Muscle Growth by Downregulating Phosphorylated Extracellular Signal–regulated Kinase 1/2, Donghwa Kim, Soomin Cho, Maria A. Castaño, Reynold A. Panettieri, Jung A. Woo, and Stephen B. Liggett

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Carotid Chemoreceptors Tune Breathing via Multipath Routing: Reticular Chain and Loop Operations Supported by Parallel Spike Train Correlations, Kendall F. Morris, Sarah C. Nuding, Lauren S. Segers, Kimberly E. Iceman, Russell O’Connor, Jay B. Dean, Mackenzie M. Ott, Pierina A. Alencar, Dale Shuman, Kofi-Kermit Horton, Thomas E. Taylor-Clark, Donald C. Bolser, and Bruce G. Lindsey

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Induction of Microvascular Network Growth in the Mouse Mesentery, Ariana D. Suarez-Martinez, Shayn M. Peirce, Brant E. Isakson, Matthew Nice, Jack Wang, Karen M. Lounsbury, Joshua P. Scallan, and Walter L. Murfee

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Structural Basis for the Antiarrhythmic Blockade of a Potassium Channel with a Small Molecule, Yoshio Takemoto, Diana P. Slough, Gretchen Meinke, Christopher Katnik, Zachary A. Graziano, Bojjibabu Chidipi, Michelle Reiser, Mohammed M. Alhadidy, Rafael Ramirez, Oscar Salvador-Montañés, Steven Ennis, Guadalupe Guerrero-Serna, Marian Haburcak, Carl Diehl, Javier Cuevas, Jose Jalife, Andrew Bohm, Yu-Shan Lin, and Sami F. Noujaim

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A Randomized Controlled Trial of Levodopa in Patients with Angelman Syndrome, Wen-Hann Tan, Lynne M. Bird, Anjali Sadhwani, Rene L. Barbieri-Welge, Steven A. Skinner, Lucia T. Horowitz, Carlos A. Bacino, Lisa M. Noll, Cary Fu, Rachel J. Hundley, Logan K. Wink, Craig A. Erickson, Gregory N. Barnes, Anne Slavotinek, Rita Jeremy, Alexander Rotenberg, Sanjeev V. Kothare, Heather E. Olson, Annapurna Poduri, Mark P. Nespeca, Hillary C. Chu, Jennifer M. Willen, Kevin F. Haas, Edwin J. Weeber, and Paul A. Rufo

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A New Low-Nephron Ckd Model With Hypertension, Progressive Decline of Renal Function, and Enhanced Inflammation in c57bl/6 Mice, Jin Wei, Jie Zhang, Lei Wang, Byeong Jake Cha, Shan Jiang, and Ruisheng Liu

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Intraluminal Pressure Triggers Myogenic Response via Activation of Calcium Spark and Calcium-Activated Chloride Channel in Rat Renal Afferent Arteriole, Kay-Pong Yip, Lavanya Balasubramanian, Chen Kan, Lei Wang, Ruisheng Liu, Luisa Ribeiro-Silva, and James S. K. Sham

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Glucose Dilates Renal Afferent Arterioles via Glucose Transporter-1, Jie Zhang, Shan Jiang, Jin Wei, Kay-Pong Yip, Lei Wang, En Yin Lai, and Ruisheng Liu

Submissions from 2017

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The Real Culprit Behind Diabetic Nephropathy: Impaired Renal Autoregulation?, Ruisheng Liu

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Neutrophil-mediated Vascular Barrier Injury: Role of Neutrophil Extracellular Traps, Jamie E. Meegan, Xiaoyuan Yang, Danielle C. Coleman, Melanie Jannaway, and Sarah Y. Yuan

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The Lymphatic System: Integral Roles in Immunity, Gwendalyn J. Randolph, Stoyan Ivanov, Bernd H. Zinselmeyer, and Joshua P. Scallan

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Structural Homologies between Phenformin, Lipitor and Gleevec Aim the Same Metabolic Oncotarget in Leukemia and Melanoma, Gábor Somlyai, T. Que Collins, Emmanuelle J. Meuillet, Patel Hitendra, Dominic P. D’Agostino, and László G. Boros

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Design of a Cluster-randomized Minority Recruitment Trial: RECRUIT, Barbara C. Tilley, Arch G. Mainous III, Daniel W. Smith, M Diane McKee, Rossybelle P. Amorrortu, Jennifer Alvidrez, Vanessa Diaz, Marvella E. Ford, Maria E. Fernandez, Robert A. Hauser, Carlos Singer, Veronica Landa, Aron Trevino, Stacia M. DeSantis, Yefei Zhang, Elvan Daniels, Derrick Tabor, and Sally W. Vernon

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A New Mouse Model of Hemorrhagic Shock-Induced Acute Kidney Injury, Lei Wang, Jiangping Song, Jacentha Buggs, Jin Wei, Shaohui Wang, Jie Zhang, Gensheng Zhang, Yan Lu, Kay-Pong Yip, and Ruisheng Liu

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Role of Intratubular Pressure During the Ischemic Phase in Acute Kidney Injury, Jin Wei, Jiangping Song, Shan Jiang, Gensheng Zhang, Donald Wheeler, Jie Zhang, Shaohui Wang, En Yin Lai, Lei Wang, Jacentha Buggs, and Ruisheng Liu

Submissions from 2016

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Rnd3 as a Novel Target to Ameliorate Microvascular Leakage, Jerome W. Breslin, Dayle A. Daines, Travis M. Doggett, Kristine H. Kurtz, Flavia M. Souza-Smith, Xun E. Zhang, Mack H. Wu, and Sarah Y. Yuan

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Natural History of Muscle Cramps in Amyotrophic Lateral Sclerosis, James B. Caress, Stephanie L. Ciarlone, Elizabeth A. Sullivan, Leah P. Griffin, and Michael S. Cartwright

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Hypothermic Osborn Waves Without Shivering Artifacts: Causes and Implications, Hesham R. Omar, Ehab El-Khabiry, Nishant Tripathi, Devanand Mangar, and Enrico M. Camporesi

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Estimation of the Pressure Drop Required for Lymph Flow through Initial Lymphatic Networks, David C. Sloas, Scott A. Stewart, Richard S. Sweat, Travis M. Doggett, Natascha G. Alves, Jerome W. Breslin, Donald P. Gaver, and Walter L. Murfee

Submissions from 2015

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Histamine Activates p38 MAP Kinase and Alters Local Lamellipodia Dynamics, Reducing Endothelial Barrier Integrity and Eliciting Central Movement of Actin Fibers, Shaquria P. Adderley, Curtis Lawrence, Eyong Madonia, Joseph O. Olubadewo, and Jerome W. Breslin

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Dendritic and Langerhans cells respond to Aβ peptides differently: implication for AD immunotherapy, Jiang Cheng, Xiaoyang Lin, David Morgan, Marcia Gordon, Xi Chen, Zhen-Hai Wang, Hai-Ning Li, Lan-Jie He, Shu-Feng Zhou, and Chuanhai Cao

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Physiology and the BRAIN Initiative, Bruce G. Lindsey

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Identification and Function of Adenosine A3 Receptor in Afferent Arterioles, Yan Lu, Rui Zhang, Ying Ge, Mattias Carlstrom, Shaohui Wang, Yiling Fu, Liang Cheng, Jin Wei, Richard J. Roman, Lei Wang, Xichun Gao, and Ruisheng Liu

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Functional Connectivity in Raphé-Pontomedullary Circuits Supports Active Suppression of Breathing During Hypocapnic Apnea, Sarah C. Nuding, Lauren S. Segers, Kimberly E. Iceman, Russell O'Connor, and Jay B. Dean

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Increased Selenoprotein P in Choroid Plexus and Cerebrospinal Fluid in Alzheimer's Disease Brain, Rachel Rueli, Arlene C. Parubrub, Andrea Dewing, Ann C. Hashimoto, Miyoko T. Bellinger, Edwin J. Weeber, Jane H. Uyehara-Lock, Lon R. White, Marla J. Berry, and Frederick P. Bellinger

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Peripheral Chemoreceptors Tune Inspiratory Drive via Tonic Expiratory Neuron Hubs in the Medullary Ventral Respiratory Column Network, L. S. Segers, S. C. Nuding, M. M. Ott, J. B. Dean, D. C. Bolser, R. O'Connor, K. F. Morris, and B. G. Lindsey

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Human Umbilical Cord Blood Cells Induce Neuroprotective Change in Gene Expression Profile in Neurons after Ischemia through Activation of Akt Pathway, M. D. Shahaduzzaman, Vijay Mehta, Jason E. Golden, Derrick D. Rowe, Suzanne Green, Ramya Tadinada, Elspeth A. Foran, Paul R. Sanberg, Keith R. Pennypacker, and Alison E. Willing

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Mechanisms of Acute Alcohol Intoxication-Induced Modulation of Cyclic Mobilization of [Ca2+] in Rat Mesenteric Lymphatic Vessels, Flavia M. Souza-Smith, Edmund K. Kerut, Jerome W. Breslin, and Patricia E. Molina

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Lymphaticosclerosis: a New Way of Thinking about Lymphatic Vessel Obstruction, A. Trujillo and J. W. Breslin

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Shear Stress Blunts Tubuloglomerular Feedback Partially Mediated by Primary Cilia and Nitric Oxide at the Macula Densa, Lei Wang, Chunyu Shen, Haifeng Liu, Shaohui Wang, Xinshan Chen, Richard J. Roman, Luis A. Juncos, Yan Lu, Jin Wei, Jie Zhang, Kay-Pong Yip, and Ruisheng Liu

Submissions from 2014

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Molecular Mechanisms of Dysautonomia During Heart Failure. Focus On “Heart Failure-Induced Changes of Voltage-Gated CA2+ Channels and Cell Excitability in Rat Cardiac Postganglionic Neurons”, Javier Cuevas

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Acute Alcohol Intoxication-Induced Microvascular Leakage, Travis M. Doggett and Jerome W. Breslin

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Female Rats are More Susceptible to Central Nervous System Oxygen Toxicity than Male Rats, Heather E. Held, Raffaele Pilla, Geoffrey E. Ciarlone, Carol S. Landon, and Jay B. Dean

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Involvement of H1 and H2 Receptors and Soluble Guanylate Cyclase in Histamine-Induced Relaxation of Rat Mesenteric Collecting Lymphatics, Kristine H. Kurtz, Andrea N. Moor, Flavia M. Souza-Smith, and Jerome W. Breslin

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Leukemia Inhibitor Factor Promotes Functional Recovery and Oligodendrocyte Survival in Rat Models of Focal Ischemia, Derrick D. Rowe, Lisa A. Collier, Hilary A. Seifert, Cortney B. Chapman, Christopher C. Leonardo, Alison E. Willing, and Keith R. Pennypacker

Submissions from 2013

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Remanent Cell Traction Force in Renal Vascular Smooth Muscle Cells Induced by Integrin-Mediated Mechanotransduction, Lavanya Balasubramanian, Chun-Min Lo, James S. K. Sham, and Kay-Pong Yip

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Validation of an Empirical Damage Model for Aging and in Vivo Injury of the Murine Patellar Tendon, Mark R. Buckley, Andrew A. Dunkman, Katherine E. Reuther, Akash Kumar, Lydia Pathmanathan, David P. Beason, David E. Birk, and Louis J. Soslowsky

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The Regulatory Roles of Small Leucine-rich Proteoglycans in Extracellular Matrix Assembly, Shoujun Chen and David E. Birk

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Effect of Age and Proteoglycan Deficiency on Collagen Fiber Re-Alignment and Mechanical Properties in Mouse Supraspinatus Tendon, Brianne K. Connizzo, Joseph J. Sarver, Renato V. Iozzo, David E. Birk, and Louis J. Soslowsky

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Therapeutic Ketosis With Ketone Ester Delays Central Nervous System Oxygen Toxicity Seizures in Rats, Dominic P. D'Agostino, Raffaele Pilla, Heather E. Held, Carol S. Landon, Michelle Puchowicz, Henri Brunengraber, Csilla Ari, Patrick Arnold, and Jay B. Dean

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Ethanol Administration Exacerbates the Abnormalities in Hepatic Lipid Oxidation in Genetically Obese Mice, Hannah Everitt, Ming Hu, Joanne M. Ajmo, Christopher Q. Rogers, Xiaomei Liang, Ray Zhang, Huquan Yin, Alison Choi, Eric S. Bennett, and Min You

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Regional Differences in Stem Cell/Progenitor Cell Populations from the Mouse Achilles Tendon, Michael J. Mienaltowski, Sheila M. Adams, and David E. Birk

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A Potential Early Physiological Marker for Cns Oxygen Toxicity: Hyperoxic Hyperpnea Precedes Seizure in Unanesthetized Rats Breathing Hyperbaric Oxygen, Raffaele Pilla, Carol S. Landon, and Jay B. Dean

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Myosin Light Chain Kinase Signaling in Endothelial Barrier Dysfunction, Robert R. Rigor, Qiang Shen, Christopher D. Pivetti, Mack H. Wu, and Sarah Y. Yuan

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ADAM15 Deficiency Attenuates Pulmonary Hyperpermeability and Acute Lung Injury in Lipopolysaccharide-Treated Mice, Chongxiu Sun, Richard S. Beard Jr, Danielle L. McLean, Robert R. Rigor, Thomas Konia, Mack H. Wu, and Sarah Y. Yuan

Submissions from 2012

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Preoperative Cardiac Evaluation of the Vascular Surgery Patient—An Anesthesia Perspective, Hesham R. Omar, Devanand Mangar, and Enrico M. Camporesi

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Central Chemoreceptor Modulation of Breathing via Multipath Tuning in Medullary Ventrolateral Respiratory Column Circuits, Mackenzie M. Ott, Sarah C. Nuding, Lauren S. Segers, Russell O'Connor, Kendall F. Morris, and Bruce G. Lindsey

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Interleukin-1β-Induced Barrier Dysfunction Is Signaled Through Pkc-θ in Human Brain Microvascular Endothelium, Robert R. Rigor, Richard S. Beard Jr., Olesya P. Litovka, and Sarah Y. Yuan

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Reelin Supplementation Recovers Sensorimotor Gating, Synaptic Plasticity and Associative Learning Deficits in the Heterozygous Reeler Mouse, Justin T. Rogers, Lisa Zhao, Justin H. Trotter, Ian Rusiana, Melinda M. Peters, Qingyou Li, Erika Donaldson, Jessica L. Banko, Kathleen E. Keenoy, G. William Rebeck, Hyang-Sook Hoe, Gabriella D’Arcangelo, and Edwin J. Weeber

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Tracking Stars: Automated Two-Dimensional Analysis of CA2+ Events. Focus On “Automated Region of Interest Analysis of Dynamic CA2+ Signals in Image Sequences”, Kay-Pong Yip and James S. K. Sham

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Global Dynamics of the Oregonator System, Yuncheng You

Submissions from 2011

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Caffeine Synergizes with Another Coffee Component to Increase Plasma GCSF: Linkage to Cognitive Benefits in Alzheimer's Mice, Chuanhai Cao, Li Wang, Xiaoyang Lin, Malgorzata Mamcarz, Chi Zhang, Ge Bai, Jasson Nong, Sam Sussman, and Gary Arendash

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Role of SIRT1-FoxO1 Signaling in Dietary Saturated Fat-Dependent Upregulation of Liver Adiponectin Receptor 2 in Ethanol-Administered Mice, Xiaomei Liang, Ming Hu, Christopher Q. Roger, Zheng Shen, and Min You

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Ventrolateral Medullary Functional Connectivity and the Respiratory and Central Chemoreceptor-Evoked Modulation of Retrotrapezoid-Parafacial Neurons, Mackenzie M. Ott, Sarah C. Nuding, Lauren S. Segers, Bruce G. Lindsey, and Kendall F. Morris

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Molecular Mechanisms of Dysautonomia During Heart Failure. Focus On “Heart Failure-Induced Changes of Voltage-Gated CA2+ Channels and Cell Excitability in Rat Cardiac Postganglionic Neurons”, Ivan Poliacek, Kendall F. Morris, Bruce G. Lindsey, Lauren S. Segers, Melanie J. Rose, Lu Wen-Chi Corrie, Cheng Wang, Teresa E. Pitts, Paul W. Davenport, and Donald C. Bolser

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Diverse Inflammatory Responses in Transgenic Mouse Models of Alzheimer's Disease and the Effect of Immunotherapy on These Responses, Donna M. Wilcock, Qun Zhao, Dave Morgan, Marcia N. Gordon, Angela Everhart, Joan G. Wilson, Jennifer E. Lee, and Carol A. Colton

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Mechanisms of Vasopressin-Induced Intracellular CA2+ Oscillations in Rat Inner Medullary Collecting Duct, Kay-Pong Yip and James S. K. Sham

Submissions from 2010

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NT-020, a Natural Therapeutic Approach to Optimize Spatial Memory Performance and Increase Neural Progenitor Cell Proliferation and Decrease Inflammation in the Aged Rat, S. Acosta, J. Jernberg, C. D. Sanberg, P. R. Sanberg, Brent J. Small, Carmelina Gemma, and Paula C. Bickford

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Hypercapnia Causes Cellular Oxidation and Nitrosation in Addition to Acidosis: Implications for CO2 Chemoreceptor Function and Dysfunction, Jay B. Dean

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Central CO2 chemoreception in cardiorespiratory control, Jay B. Dean and Eugene E. Nattie

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Hyperbaric Hyperoxia and Normobaric Reoxygenation Increase Excitability and Activate Oxygen-induced Potentiation in CA1 Hippocampal Neurons, Alfredo J. Garcia III, Robert W. Putnam, and Jay B. Dean

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Hyperoxic Stimulation of Synchronous Orthodromic Activity and Induction of Neural Plasticity Does Not Require Changes in Excitatory Synaptic Transmission, Alfredo J. Garcia III, Robert W. Putnam, and Jay B. Dean

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Respiratory and Mayer Wave-Related Discharge Patterns of Raphé and Pontine Neurons Change With Vagotomy, K. F. Morris, S. C. Nuding, L. S. Segers, D. M. Baekey, R. Shannon, B. G. Lindsey, and T. E. Dick

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Involvement of Adiponectin-SIRT1-Ampk Signaling in the Protective Action of Rosiglitazone Against Alcoholic Fatty Liver in Mice, Zheng Shen, Xiaomei Liang, Christopher Q. Rogers, Drew Rideout, and Min You

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Brachial Plexus Injury Following Spinal Surgery, Juan S. Uribe, Jaya Kolla, Hesham Omar, Elias Dakwar, Naomi Abel, Devanand Mangar, and Enrico Camporesi

Submissions from 2009

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PH Regulating Transporters in Neurons From Various Chemosensitive Brainstem Regions in Neonatal Rats, Anna E. Kersh, Lynn K. Hartzler, Kevin Havlin, Brittany Belcastro Hubbell, Vivian Nanagas, Avash Kalra, Jason Chua, Ryan Whitesell, Nick A. Ritucci, Jay B. Dean, and Robert W. Putnam