Neutrophil-mediated Vascular Barrier Injury: Role of Neutrophil Extracellular Traps

Authors

Jamie E. Meegan, University of South Florida
Xiaoyuan Yang, University of South FloridaFollow
Danielle C. Coleman, University of South Florida
Melanie Jannaway, University of South FloridaFollow
Sarah Y. Yuan, University of South FloridaFollow

Document Type

Article

Publication Date

2017

Keywords

endothelial barrier dysfunction, neutrophil extracellular traps, vascular hyperpermeability

Digital Object Identifier (DOI)

https://doi.org/10.1111/micc.12352

Abstract

Neutrophils play an essential role in host defense against infection or injury. While neutrophil activation is necessary for pathogen clearance and tissue repair, a hyperactive response can lead to tissue damage and microcirculatory disorders, a process involving complex neutrophil–endothelium cross talk. This review highlights recent research findings about neutrophil-mediated signaling and structural changes, including those induced by neutrophil extracellular traps, which ultimately lead to vascular barrier injury.

Was this content written or created while at USF?

Yes

Citation / Publisher Attribution

Microcirculation, v. 24, issue 3, art. e12352

Scholar Commons Citation

Meegan, Jamie E.; Yang, Xiaoyuan; Coleman, Danielle C.; Jannaway, Melanie; and Yuan, Sarah Y., "Neutrophil-mediated Vascular Barrier Injury: Role of Neutrophil Extracellular Traps" (2017). Molecular Pharmacology & Physiology Faculty Publications. 15.
https://digitalcommons.usf.edu/mpp_facpub/15