Increased Selenoprotein P in Choroid Plexus and Cerebrospinal Fluid in Alzheimer's Disease Brain
Document Type
Article
Publication Date
2015
Keywords
Alzheimer's disease, cerebrospinal fluid, choroid plexus, selenium, selenoprotein P, selenoproteins, Sepp1
Digital Object Identifier (DOI)
https://doi.org/10.3233/JAD-141755
Abstract
Subjects with Alzheimer's disease (AD) have elevated brain levels of the selenium transporter selenoprotein P (Sepp1). We investigated if this elevation results from increased release of Sepp1 from the choroid plexus (CP). Sepp1 is significantly increased in CP from AD brains in comparison to non-AD brains. Sepp1 localizes to the trans-Golgi network within CP epithelia, where it is processed for secretion. The cerebrospinal fluid from AD subjects also contains increased levels Sepp1 in comparison to non-AD subjects. These findings suggest that AD pathology induces increased levels of Sepp1 within CP epithelia for release into the cerebrospinal fluid to ultimately increase brain selenium.
Was this content written or created while at USF?
Yes
Citation / Publisher Attribution
Journal of Alzheimer's Disease, v. 44, issue 2, p. 379-383
Scholar Commons Citation
Rueli, Rachel; Parubrub, Arlene C.; Dewing, Andrea; Hashimoto, Ann C.; Bellinger, Miyoko T.; Weeber, Edwin J.; Uyehara-Lock, Jane H.; White, Lon R.; Berry, Marla J.; and Bellinger, Frederick P., "Increased Selenoprotein P in Choroid Plexus and Cerebrospinal Fluid in Alzheimer's Disease Brain" (2015). Molecular Pharmacology & Physiology Faculty Publications. 41.
https://digitalcommons.usf.edu/mpp_facpub/41
