The Regulatory Roles of Small Leucine-rich Proteoglycans in Extracellular Matrix Assembly
Document Type
Article
Publication Date
2013
Keywords
cell-matrix interactions, collagen, development, extracellular matrix, fibrillogenesis, glycosaminoglycans, human congenital stromal corneal dystrophy, pathophysiology, proteoglycans, SLRP
Digital Object Identifier (DOI)
https://doi.org/10.1111/febs.12136
Abstract
Small leucine-rich proteoglycans (SLRPs) are involved in a variety of biological and pathological processes. This review focuses on their regulatory roles in matrix assembly. SLRPs have protein cores and hypervariable glycosylation with multivalent binding abilities. During development, differential interactions of SLRPs with other molecules result in tissue-specific spatial and temporal distributions. The changing expression patterns play a critical role in the regulation of tissue-specific matrix assembly and therefore tissue function. SLRPs play significant structural roles within extracellular matrices. In addition, they play regulatory roles in collagen fibril growth, fibril organization and extracellular matrix assembly. Moreover, they are involved in mediating cell–matrix interactions. Abnormal SLRP expression and/or structures result in dysfunctional extracellular matrices and pathophysiology. Altered expression of SLRPs has been found in many disease models, and structural deficiency also causes altered matrix assembly. SLRPs regulate assembly of the extracellular matrix, which defines the microenvironment, modulating both the extracellular matrix and cellular functions, with an impact on tissue function.
Was this content written or created while at USF?
Yes
Citation / Publisher Attribution
The FEBS Journal, v. 280, issue 10, p. 2120-2137
Scholar Commons Citation
Chen, Shoujun and Birk, David E., "The Regulatory Roles of Small Leucine-rich Proteoglycans in Extracellular Matrix Assembly" (2013). Molecular Pharmacology & Physiology Faculty Publications. 69.
https://digitalcommons.usf.edu/mpp_facpub/69
