Theses/Dissertations from 2024
3D Organ-Scale Models of Tumor Growth and Treatment, Rafael Ramon Bravo
Group B Streptococcus Intestinal Barrier Disruption and the Protective Role of Butyrate, Kristen Dominguez
SARS-CoV-2 Neurotropism: Understanding Effects at the Blood-Brain Barrier and Hematogenous Neuroinvasiveness, Taylor E. Martinez
Elucidating the role of the tumor suppressor gene RNA-binding motif 5 (RBM5) in models of traumatic brain injury, Kara L. Snyder
Theses/Dissertations from 2023
Nrf2 Sequestration by SSH1 Tips the Balance from Neuroprotection to Neurodegeneration in Alzheimer’s Disease, Sara G. Cazzaro Buosi
A Forward Genetic Screen Identifies Genes Involved in Gametocyte Development of the Human Malaria Parasite Plasmodium falciparum., Jyotsna Chawla
A Novel Role for eNOS in Regulating Lymphatic Valve Development During Embryogenesis, Drishya Iyer
Bioinformatic Analysis Predicts Microglial Dysfunction in Murine Aging, Amadu Idrisa Jalloh
Withaferin A and Immune Checkpoint Blocker Therapy for the Treatment of Non-Small Cell Lung Cancer, Roukiah Khalil
Vascular and Auditory Changes after Repetitive Traumatic Brain Injury, Courtney Lynn Penn
Partial Characterization of Plasmodium falciparum Genes Implicated in Altered Artemisinin Stress Response, Caroline F. Simmons
Theses/Dissertations from 2022
Structural and Biochemical Characterization of Epigenetic and Fusion Tyrosine Kinase Cancer Targets for Drug Development, Melissa Bikowitz
Neural and Cardiac Mechanisms in Friedreich's Ataxia with Patient-derived iPSCs, Mariana Burgos Angulo
Atrial Fibrillation in Aging: Mechanisms and Potential Therapeutics, Mengmeng Chang
Effect of Hyperoxia on Cardiac Pathophysiology in Female Guinea Pig Hearts, Chayapatou Chayawatto
Role of BMI1 in Acute Lung Injury, María Helena Hernández-Cuervo
Defining and Modeling Pericyte-Induced Capillary Network Assembly, Capillary Regression Preceding Pericyte-Stimulated Fibrosis, and Lymphatic Capillary Regression, Scott Stephen Kemp
Glucose Homeostasis in Human Diabetic Adipocytes: Role of GLP1 in Sortilin Alternative Splicing, Ashley Lui
Impact of Arginine Metabolism and Sensing in Mouse Models of Alzheimer’s Disease, Chao Ma
Reelin Supplementation for the Rescue of Fragile X Syndrome., Nicole K. Morrill
Investigations into the Improvement of Angelman Syndrome Therapeutics, Austin W. Nenninger
The Role of Protein Palmitoylation in Two Disorders; X-Linked Intellectual Disability and COVID-19, Ahmed A. Ramadan
Small heat shock protein 22 preserves neuronal function in a murine model of tauopathy, Santiago Rodriguez Ospina
Phenotypic Variability in iPSC-Induced Cardiomyocytes and Cardiac Fibroblasts Carrying Diverse LMNA Mutations, Jiajia Yang
X-linked Ubiquitin-Specific Peptidase 11 Increases Tauopathy Vulnerability in Women, Yan Yan
Theses/Dissertations from 2021
Hyperoxia-Induced Cardiac Pathophysiology in Guinea Pig Hearts, Zain ul Abidin
Activity-dependent Regulation of Extracellular UBE3A in a Novel Angelman Syndrome Rat Model, Andie Dodge
Contribution of Retinal Ganglion Cells to Brown-Norway Rat Spatiotemporal Visual Perception and the Electroretinogram, Nicholas P. Johnson
Mechanistic Insight into β-Lactamase Catalysis, Inhibitor Design and Resistance, Michael Trent Kemp
Application of Gold Nanoshells for Photothermal Therapy in Lung Cancer Cells, Yva K. Luc
Drug Candidates Targeting Hsp90/Cdc37 for the Treatment of Neurodegenerative Disease, Ryan Martin
A Study of TRPA1 Activation via Covalent Electrophilic Modification of Cysteines, Thomas A. Parks
Targeting Modern Pathogens with Rational Drug Design, Michael Dominic Sacco
Effects of Exogenous Ketone Therapy on Performance, Cardiorespiration, and Seizure Genesis During Exposure to HBO2 in the Sprague Dawley Rat, Nicole M. Stavitzski
Role of NHE3 in the intestine and thick ascending limb of the kidneys, Jianxiang Xue
Metastatic MAT Phenotype Driven by Noncanonical EphA2 Signaling in Melanoma, Chao Zhang
Theses/Dissertations from 2020
Hyaluronic Acid Coated Targeted Lipid Micellar Nanoparticle as a Delivery Vehicle for Lapatinib and Ketoconazole in EGFR mutated Lung Cancer, Nadia Tasnim Ahmed
Structure Based Inhibitor Discovery Targeting Multiple β-Lactamases Involved in Antibiotic Resistance, Afroza Akhtar
SSH1 Impedes p62/SQSTM1 Flux and Tau Clearance Independent of Cofilin Activation, Cenxiao Fang
Testing Glutathione-S-Transferase Mu 1 (GSTM1) in Protecting Retinal Pigment Epithelium Cells from Oxidative Stress, Inyoung C. Garner
Role of Thyroid Hormone Modulating Astrocyte Activation, Payal Ghosh
Synthesis of a Targeted pH Responsive Nanoparticle for Controlled Release of Actinomycin D, Alejandro Jesus Gonzalez
Discovery and Characterization of Small Molecule Inhibitors of Bromodomains, Md Rezaul Karim
Targeting Cancer-Anorexia Cachexia Syndrome and Septic Inflammatory-Based Atrophy With R/S 1,3 Butanediol Acetoacetate Diester, Andrew P. Koutnik
Cognition in Health and Disease: Two Mouse Model Studies, Heather Lynn Mahoney
Functional Significance of Endothelial Sigma-1 Receptors in Vascular Reactivity and Barrier Function, Zeinab Y. Motawe
Mass Spectrometry Discovery-Based Proteomics to Examine Anti-Aging Effects of the Nutraceutical NT-020 in Rat Serum, Samantha M. Portis
Dendriplex - Cyclodextrin conjugates for Gene delivery to Retina, Durga Deepak Puro
Immune Modulation as a Therapeutic Target in an α-synuclein Model of Parkinson’s Disease, Meena Subhashini Subbarayan
Role of Serum Amyloid P Component in the Pathogenesis of Chronic Traumatic Encephalopathy, Brittany Urban
Theses/Dissertations from 2019
Intrinsically Disorder Proteins and Liquid-Liquid Phase Transitions in Neurodegenerative Diseases, April Lynn Darling
Genomics and Transcriptomics Approaches to Understanding Drug Resistance Mechanisms in the Malaria Parasite Plasmodium falciparum, Justin Allan Gibbons
Lung Cancer Cells Survive EGFR TKI Exposure Through Upregulation of Cholesterol Synthesis, Mark Howell
Targeting Bacterial Resistance and Cancer Metastasis: A Structure Based Approach, Kyle Galen Kroeck
Design and Delivery of Synthetic mRNA by a Peptide Nanoparticle, John H. Lockhart
Investigating the Role of the Chromosome 19 MicroRNA Cluster in Human Trophoblast Differentiation and Infantile Hemangioma, Ezinne Francess Mong
An Eye Opener in Stroke: Mitochondrial Dysfunction and Stem Cell Repair in Stroke-induced Retinal Ischemia, Hung Vu Thien Nguyen
A Small RNA and DNA Binding Protein Contribute to Biofilm Development in Bartonella henselae, Udoka Okaro
Targeting PTEN for Therapy in Cancer and PTENopathies, Emily Palumbo
Contribution of Retrotransposons to Breast Cancer Malignancy, Isaac D. Raplee
Roux-en-Y Gastric Bypass Attenuates Obesity-Related Liver Injury, Drew Alan Rideout
Evaluation of Novel Hemocompatible Surface Coatings for Extracorporeal Life Support: A Biocompatible Alternative to Systemic Anticoagulation, Teryn Rose Roberts
Theses/Dissertations from 2018
Mechanisms of S1P-Induced Endothelial Barrier Enhancement, Natascha Guimarães Alves
Cyclophilin 40 as a Novel Disaggregase, Jeremy Dustin Baker
Investigating the Role of the RNA Binding Protein LIN28 in the Human Placenta: Implications for Preeclampsia, John Canfield
Proteolysis of CX3CL1 Impacts CX3CR1 Signaling and Therapeutic Benefits in a Tauopathy Model, Dylan John Finneran
Actinomycin D and Telmisartan Combination Therapy Targets Lung Cancer Stem Cells, Ryan Green
Therapeutic modulation of Alzheimer’s disease with biological (HUCBS) and pharmacological (LISPRO) approaches, Md Ahsan Habib
The role of pulmonary stretch receptor afferents in swallow-breathing coordination: a comparison of central respiratory rhythm versus mechanical ventilation on swallow in a decerebrate feline model, Kofi-Kermit A. Horton
Neutrophil Extracellular Traps and Vascular Barrier Injury, Jamie E. Meegan
Targeting the Hsp90/Aha1 Complex for the Treatment of Tauopathies, Lindsey Brooke Shelton
Integrative Signaling of Mitochondria, TRPA1 and TRPV1 in Vagal Neurons, Katherine Stanford
Theses/Dissertations from 2017
Receptor-Associated Protein (RAP) Models In Vivo Reelin Haploinsufficiency: Implications in Schizophrenia, Jamileh Ahmed
The Potential Role of Antiretroviral Efavirenz in HIV Associated Neurocognitive Disorders, Lecia Ashanna Moya Brown
The Role of Elevated Hyaluronan-Mediated Motility Receptor (RHAMM/HMMR) in Ovarian Cancer, Stephanie T. Buttermore
Mass-spectrometry Based Proteomics of Age-related Changes in Murine Microglia, Antwoine Flowers
Astaxanthin Attenuates MPTP Induced Neurotoxicity and Modulates Cognitive Function in Aged Mice, Beth Grimmig
Microfluidic Biopsy Trapping Device for the Real-time Monitoring of the Tumor Microenvironment, Angela Holton
Identifying New Treatment Options and Risk Factors for Type 2 Diabetes: The Potential Role of Thymoquinone and Persistent Organic Pollutants, Shpetim Karandrea
Acetaminophen Associated Neurotoxicity and its Relevance to Neurodevelopmental Disorders, Seol-Hee Kim
Synthesis, in vitro Characterization and Applications of Novel 8-Aminoquinoline Fluorescent Probes, Adonis McQueen
Role of Amylase in Ovarian Cancer, Mai Mohamed
Computational Analysis of Protein Intrinsic Disorder in Human Diseases, Insung Na
Mechanism Elucidation and Inhibitor Discovery against Serine and Metallo-Beta-Lactamases Involved in Bacterial Antibiotic Resistance, Orville A. Pemberton
osteopontin plays a pivotal role in in increasing severity of respiratory syncytial virus infection, Viviana Sampayo-Escobar
Tau-Directed Immunotherapy for Alzheimer’s Disease, Sulana Kay Schroeder
Therapeutic Modulation of Cancer Metabolism with Dichloroacetate and Metformin, Nathan Patrick Ward
Acute Kidney Injury and Chronic Kidney Disease, Jin Wei
Regulation of Extracellular Signal-Regulated Kinase by Histone Deacetylase 6, Jheng-Yu Wu
Glomerular Hyperfiltration and Hypertension in Diabetes, Jie Zhang
S1P-Mediated Endothelial Barrier Enhancement: Role of Rho Family GTPases and Local Lamellipodia, Xun E. Zhang
Theses/Dissertations from 2016
Antimalarial Exoerythrocytic Stage Drug Discovery and Resistance Studies, Lynn Dong Blake
Respiratory Syncytial Virus-infected Mesenchymal Stem Cells Regulate Immunity via Interferon-beta and Indoleamine-2,3-dioxygenase, Michael B. Cheung
Hypercapnic Hyperoxia Increases Free Radical Production and Cellular Excitability in Rat Caudal Solitary Complex Brain Slice Neurons, Geoffrey Edward Ciarlone
The Effects of Synthetic and Dietary Therapeutics on Learning, Memory, Motor Coordination, and Seizure in an Angelman Syndrome Mouse Model, Stephanie Lynn Ciarlone
Leukemia Inhibitory Factor as a Neuroprotective Agent against Focal Cerebral Ischemia, Stephanie Davis
