Sars-cov-2, COVID-19, Variant, Sublineage, Transmission, Immunity, Infection, Vaccination, Non-pharmaceutical Interventions
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The scientific, private, and industrial sectors use a wide variety of technological platforms available to achieve protection against SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), including vaccines. However, the virus evolves continually into new highly virulent variants, which might overcome the protection provided by vaccines and may re-expose the population to infections. Mass vaccinations should be continued in combination with more or less mandatory non-pharmaceutical interventions. Therefore, the key questions to be answered are: (i) How to identify the primary and secondary infections of SARS-CoV-2? (ii) Why are neutralizing antibodies not long-lasting in both cases of natural infections and post-vaccinations? (iii) Which are the factors responsible for this decay in neutralizing antibodies? (iv) What strategy could be adapted to develop long-term herd immunity? (v) Is the Spike protein the only vaccine target or is a vaccine cocktail better?
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Citation / Publisher Attribution
Epidemiologia, v. 3, issue 2, p. 229-237
Scholar Commons Citation
Redwan, Elrashdy M.; Elrashdy, Fatma; Aljabali, Alaa A.A.; Baetas-da-Cruz, Wagner; Barh, Debmalya; Brufsky, Adam M.; Sarif Hassan, Sk.; Lundstrom, Kenneth; Serrano-Aroca, Ángel; Takayama, Kazuo; Tambuwala, Murtaza M.; Uhal, Bruce D.; and Uversky, Vladimir N., "Would New SARS-CoV-2 Variants Change the War against COVID-19?" (2022). Molecular Medicine Faculty Publications. 972.