Would New SARS-CoV-2 Variants Change the War against COVID-19?

Authors

Elrashdy M. Redwan, King Abdulaziz University
Fatma Elrashdy, Cairo University
Alaa A.A. Aljabali, Yarmouk University
Wagner Baetas-da-Cruz, Federal University of Rio de Janeiro (UFRJ)
Debmalya Barh, Institute of Integrative Omics and Applied Biotechnology (IIOAB)
Adam M. Brufsky, University of Pittsburgh School of Medicine
Sk. Sarif Hassan, Pingla Thana Mahavidyalaya
Kenneth Lundstrom, PanTherapeutics
Ángel Serrano-Aroca, Universidad Católica de Valencia San Vicente Mártir
Kazuo Takayama, Kyoto University
Murtaza M. Tambuwala, Ulster University
Bruce D. Uhal, Michigan State University
Vladimir N. Uversky, University of South FloridaFollow

Document Type

Article

Publication Date

2022

Keywords

Sars-cov-2, COVID-19, Variant, Sublineage, Transmission, Immunity, Infection, Vaccination, Non-pharmaceutical Interventions

Digital Object Identifier (DOI)

https://doi.org/10.3390/epidemiologia3020018

Abstract

The scientific, private, and industrial sectors use a wide variety of technological platforms available to achieve protection against SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), including vaccines. However, the virus evolves continually into new highly virulent variants, which might overcome the protection provided by vaccines and may re-expose the population to infections. Mass vaccinations should be continued in combination with more or less mandatory non-pharmaceutical interventions. Therefore, the key questions to be answered are: (i) How to identify the primary and secondary infections of SARS-CoV-2? (ii) Why are neutralizing antibodies not long-lasting in both cases of natural infections and post-vaccinations? (iii) Which are the factors responsible for this decay in neutralizing antibodies? (iv) What strategy could be adapted to develop long-term herd immunity? (v) Is the Spike protein the only vaccine target or is a vaccine cocktail better?

Rights Information

This work is licensed under a Creative Commons Attribution 4.0 License.

Was this content written or created while at USF?

Yes

Citation / Publisher Attribution

Epidemiologia, v. 3, issue 2, p. 229-237

Scholar Commons Citation

Redwan, Elrashdy M.; Elrashdy, Fatma; Aljabali, Alaa A.A.; Baetas-da-Cruz, Wagner; Barh, Debmalya; Brufsky, Adam M.; Sarif Hassan, Sk.; Lundstrom, Kenneth; Serrano-Aroca, Ángel; Takayama, Kazuo; Tambuwala, Murtaza M.; Uhal, Bruce D.; and Uversky, Vladimir N., "Would New SARS-CoV-2 Variants Change the War against COVID-19?" (2022). Molecular Medicine Faculty Publications. 972.
https://digitalcommons.usf.edu/mme_facpub/972