Document Type
Article
Publication Date
2022
Keywords
COVID-19, Cytokine Storm, Efferocytosis, Hypochlorous Acid, Macrophage Polarization, Myeloperoxidase, Sars-cov-2, Taurine
Digital Object Identifier (DOI)
https://doi.org/10.37349/emed.2022.00088
Abstract
Around the world, more than 6.2 million individuals have died as a result of coronavirus disease 2019 (COVID-19). According to a recent survey conducted among immunologists, epidemiologists, and virologists, this disease is expected to become endemic. This implies that the disease could have a continuous presence and/or normal frequency in the population. Pharmacological interventions to prevent infection, as well as to treat the patients at an early phase of illness to avoid hospitalization are essential additions to the vaccines. Taurine is known to inhibit the generation of all inflammatory mediators linked to the cytokine storm. It can also protect against lung injury by suppressing increased oxidants production and promoting the resolution of the inflammatory process. Neutrophil lactoferrin degranulation stimulated by taurine may have antiviral effects against SARS-CoV-2, limiting viral replication. It is hypothesized that if taurine is administered early in the onset of COVID-19 disease, it may stop the cytokine storm from progressing, lowering morbidity and mortality.
Rights Information
This work is licensed under a Creative Commons Attribution 4.0 License.
Was this content written or created while at USF?
Yes
Citation / Publisher Attribution
Exploration of Medicine, v. 3, p. 234-248
Scholar Commons Citation
Rubio-Casillas, Alberto; Gupta, Ramesh C.; Redwan, Elrashdy M.; Uversky, Vladimir N.; and Badierah, Raied A., "Early Taurine Administration as a Means for Halting the Cytokine Storm Progression in COVID-19 Patients" (2022). Molecular Medicine Faculty Publications. 966.
https://digitalcommons.usf.edu/mme_facpub/966
