Unfoldomics of Prostate Cancer on the Abundance and Roles of Intrinsically Disordered Proteins in Prostate Cancer
Document Type
Article
Publication Date
2016
Digital Object Identifier (DOI)
https://doi.org/10.4103%2F1008-682X.184999
Abstract
Prostatic diseases such as prostate cancer and benign prostatic hyperplasia are highly prevalent among men. The number of studies focused on the abundance and roles of intrinsically disordered proteins in prostate cancer is rather limited. The goal of this study is to analyze the prevalence and degree of disorder in proteins that were previously associated with the prostate cancer pathogenesis and to compare these proteins to the entire human proteome. The analysis of these datasets provides means for drawing conclusions on the roles of disordered proteins in this common male disease. We also hope that the results of our analysis can potentially lead to future experimental studies of these proteins to find novel pathways associated with this disease.
Was this content written or created while at USF?
Yes
Citation / Publisher Attribution
Asian Journal of Andrology, v. 18, issue 5, p. 662-672
Scholar Commons Citation
Landau, Kevin S.; Na, Insung; Schenk, Ryan O.; and Uversky, Vladimir N., "Unfoldomics of Prostate Cancer on the Abundance and Roles of Intrinsically Disordered Proteins in Prostate Cancer" (2016). Molecular Medicine Faculty Publications. 869.
https://digitalcommons.usf.edu/mme_facpub/869
