When Good Goes Awry: The Aggregation of Protein Therapeutics
Document Type
Article
Publication Date
2017
Keywords
Aggregation, Antibodies, Delivery, Formulation, Glucagon, Insulin, Storage.
Abstract
Protein therapeutics are playing an increasingly important role in treatment of a variety of human diseases. However, like the rest of proteins, they are susceptible to aggregation. Aggregation of proteinaceous pharmaceuticals can cause a loss of efficacy and, potentially, cytotoxicity and an immunogenic response. This review describes various ways protein therapeutics aggregate and a variety of approaches taken to prevent or minimize this process.
Was this content written or created while at USF?
Yes
Citation / Publisher Attribution
Protein & Peptide Letters, v. 24, issue 4, p. 340-347
Scholar Commons Citation
Redington, Jeniffer M.; Breydo, Leonid; and Uversky, Vladimir N., "When Good Goes Awry: The Aggregation of Protein Therapeutics" (2017). Molecular Medicine Faculty Publications. 861.
https://digitalcommons.usf.edu/mme_facpub/861
