Document Type
Article
Publication Date
2020
Keywords
Tetratricopeptide Repeat, Intrinsically Disordered Protein, Intrinsically Disordered Protein Region, Protein-protein Interaction, Posttranslational Modification
Digital Object Identifier (DOI)
https://doi.org/10.3390/ijms21103709
Abstract
Among the realm of repeat containing proteins that commonly serve as “scaffolds” promoting protein-protein interactions, there is a family of proteins containing between 2 and 20 tetratricopeptide repeats (TPRs), which are functional motifs consisting of 34 amino acids. The most distinguishing feature of TPR domains is their ability to stack continuously one upon the other, with these stacked repeats being able to affect interaction with binding partners either sequentially or in combination. It is known that many repeat-containing proteins are characterized by high levels of intrinsic disorder, and that many protein tandem repeats can be intrinsically disordered. Furthermore, it seems that TPR-containing proteins share many characteristics with hybrid proteins containing ordered domains and intrinsically disordered protein regions. However, there has not been a systematic analysis of the intrinsic disorder status of TPR proteins. To fill this gap, we analyzed 166 human TPR proteins to determine the degree to which proteins containing TPR motifs are affected by intrinsic disorder. Our analysis revealed that these proteins are characterized by different levels of intrinsic disorder and contain functional disordered regions that are utilized for protein-protein interactions and often serve as targets of various posttranslational modifications.
Rights Information
This work is licensed under a Creative Commons Attribution 4.0 License.
Was this content written or created while at USF?
Yes
Citation / Publisher Attribution
International Journal of Molecular Sciences, v. 21, issue 10, art. 3709
Scholar Commons Citation
Bibber, Nathan W.; Haerle, Cornelia; Khalifa, Roy; Xue, Bin; and Uversky, Vladimir N., "Intrinsic Disorder in Tetratricopeptide Repeat Proteins" (2020). Molecular Medicine Faculty Publications. 836.
https://digitalcommons.usf.edu/mme_facpub/836
