Structural and Functional Properties of Il-4δ2, an Alternative Splice Variant of Human IL-4
Interleukin 4, Interleukine Recepto, Splice Variant, Cytokine, Four-helix-bundle Cytokine
Digital Object Identifier (DOI)
Structural and functional properties of recombinant IL-4δ2, a naturally occurring splice variant of human IL-4 with a deletion of the loop region 22−37, have been analyzed. IL-4δ2 has α-helical structure and most likely preserves the “up−up−down−down” topology typical of the four-helix-bundle cytokines. IL-4δ2 interacts specifically with the α chain of IL-4R and competes effectively with IL-4 for the common binding sites. Thus, IL-4δ2 may act as a regulator of the cytokine net, being the natural antagonist of IL-4.
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Citation / Publisher Attribution
Journal of Proteome Research, v. 2, issue 3, p. 273-281
Scholar Commons Citation
Vasiliev, Anatoly M.; Vasilenko, Raisa; Kulikova, Natalia; Andreev, Sergey M.; Chikileva, Irina O.; Puchkova, Galina Yu; Kosarev, Igor V.; Khodyakova, Anna V.; Khlebnikov, Valentin; Ptitsyn, Leonid R.; Shcherbakov, Grygory Ya.; Uversky, Vladimir N.; DuBuske, Lawrence M.; and Abramov, Vyacheslav, "Structural and Functional Properties of Il-4δ2, an Alternative Splice Variant of Human IL-4" (2003). Molecular Medicine Faculty Publications. 708.