Structural and Functional Properties of Il-4δ2, an Alternative Splice Variant of Human IL-4

Authors

Anatoly M. Vasiliev, Institute of Immunological Engineering
Raisa Vasilenko, Institute of Immunological Engineering
Natalia Kulikova, Institute of Immunological Engineering
Sergey M. Andreev, Institute of Immunological Engineering
Irina O. Chikileva, Institute of Immunological Engineering
Galina Yu Puchkova, Institute of Immunological Engineering
Igor V. Kosarev, Institute of Immunological Engineering
Anna V. Khodyakova, Institute of Immunological Engineering
Valentin Khlebnikov, Institute of Immunological Engineering
Leonid R. Ptitsyn, Institute of Immunological Engineering
Grygory Ya. Shcherbakov, Institute of Immunological Engineering
Vladimir N. Uversky, University of California, Santa CruzFollow
Lawrence M. DuBuske, Immunology Research Institute of New England
Vyacheslav Abramov, Institute of Immunological Engineering

Document Type

Article

Publication Date

2003

Keywords

Interleukin 4, Interleukine Recepto, Splice Variant, Cytokine, Four-helix-bundle Cytokine

Digital Object Identifier (DOI)

https://doi.org/10.1021/pr025586y

Abstract

Structural and functional properties of recombinant IL-4δ2, a naturally occurring splice variant of human IL-4 with a deletion of the loop region 22−37, have been analyzed. IL-4δ2 has α-helical structure and most likely preserves the “up−up−down−down” topology typical of the four-helix-bundle cytokines. IL-4δ2 interacts specifically with the α chain of IL-4R and competes effectively with IL-4 for the common binding sites. Thus, IL-4δ2 may act as a regulator of the cytokine net, being the natural antagonist of IL-4.

Was this content written or created while at USF?

Yes

Citation / Publisher Attribution

Journal of Proteome Research, v. 2, issue 3, p. 273-281

Scholar Commons Citation

Vasiliev, Anatoly M.; Vasilenko, Raisa; Kulikova, Natalia; Andreev, Sergey M.; Chikileva, Irina O.; Puchkova, Galina Yu; Kosarev, Igor V.; Khodyakova, Anna V.; Khlebnikov, Valentin; Ptitsyn, Leonid R.; Shcherbakov, Grygory Ya.; Uversky, Vladimir N.; DuBuske, Lawrence M.; and Abramov, Vyacheslav, "Structural and Functional Properties of Il-4δ2, an Alternative Splice Variant of Human IL-4" (2003). Molecular Medicine Faculty Publications. 708.
https://digitalcommons.usf.edu/mme_facpub/708