Biophysical Constraints for Protein Structure Prediction
Document Type
Article
Publication Date
2002
Keywords
Protein, Structure, Folding, Molecular Dimension, Prediction
Digital Object Identifier (DOI)
https://doi.org/10.1021/pr025552q
Abstract
Though highly desirable, neither a single experimental technique nor a computational approach can be sufficient enough to rationalize a protein structure. The incorporation of biophysical constraints, which can be rationalized based on conventional biophysical measurements, might lead to considerable improvement of the simulation procedures. In this regard, our analysis of 180 proteins in different conformational states allows prediction of the overall protein dimension based on the chain length, i.e., the protein molecular weight, with an accuracy of 10%.
Was this content written or created while at USF?
No
Citation / Publisher Attribution
Journal of Proteome Research, v. 2, issue 1, p. 37-42
Scholar Commons Citation
Tcherkasskaya, Olga; Davidson, Eugene A,; and Uversky, Vladimir N., "Biophysical Constraints for Protein Structure Prediction" (2002). Molecular Medicine Faculty Publications. 699.
https://digitalcommons.usf.edu/mme_facpub/699
