Secondary Structure of The Homologous Proteins, A A-fetoprotein and Serum Albumin, from Their Circular Dichroism and Infrared Spectra
Document Type
Article
Publication Date
2001
Keywords
Proteins Fetoprotein, Serum Albumin, Circular Dichroism, Human Serum Albumin (HSA)
Digital Object Identifier (DOI)
http://dx.doi.org/10.2174/0929866013409391
Abstract
Secondary structure composition of two homologous proteins, alpha-fetoprotein and serum albumin, has been compared using circular dichroism and Fourier-transform infrared spectroscopy. CD-only analysis gives an accurate a-helical content for SA, but underestimates the predicted value for AFP. In contrast, FTIR-only analysis underestimates the helical content of SA. However, analysis of hybrid IR-CD spectra gives more accurate values for secondary structure composition for both AFP and SA and shows that the secondary structures of these proteins are the same.
Was this content written or created while at USF?
Yes
Citation / Publisher Attribution
Protein & Peptide Letters, v. 8, issue 4, p. 297-302
Scholar Commons Citation
Oberg, Keith A. and Uversky, Vladimir N., "Secondary Structure of The Homologous Proteins, A A-fetoprotein and Serum Albumin, from Their Circular Dichroism and Infrared Spectra" (2001). Molecular Medicine Faculty Publications. 673.
https://digitalcommons.usf.edu/mme_facpub/673
