Antibacterial Properties and Atomic Resolution X-ray Complex Crystal Structure of a Ruthenocene Conjugated β-lactam Antibiotic
Digital Object Identifier (DOI)
We have determined a 1.18 Å resolution X-ray crystal structure of a novel ruthenocenyle-6-aminopenicillinic acid in complex with CTX-M β-lactamase, showing unprecedented details of interactions between ruthenocene and protein. As the first product complex with an intact catalytic serine, the structure also offers insights into β-lactamase catalysis and inhibitor design.
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Citation / Publisher Attribution
Chemical Communication, v. 51, 6186-6189
Scholar Commons Citation
Lewandowski, Eric M.; Skiba, Joanna; Torelli, Nicholas J.; Rajnisz, Aleksandra; Solecka, Jolanta; Kowalski, Konrad; and Chen, Yu, "Antibacterial Properties and Atomic Resolution X-ray Complex Crystal Structure of a Ruthenocene Conjugated β-lactam Antibiotic" (2015). Molecular Medicine Faculty Publications. 64.