Antibacterial Properties and Atomic Resolution X-ray Complex Crystal Structure of a Ruthenocene Conjugated β-lactam Antibiotic

Authors

Eric M. Lewandowski, University of South FloridaFollow
Joanna Skiba, University of Łódź
Nicholas J. Torelli, University of South Florida
Aleksandra Rajnisz, National Institute of Public Health-National Institute of Hygiene
Jolanta Solecka, National Institute of Public Health-National Institute of Hygiene
Konrad Kowalski, University of Łódź
Yu Chen, University of South FloridaFollow

Document Type

Article

Publication Date

2015

Digital Object Identifier (DOI)

https://doi.org/10.1039/C5CC00904A

Abstract

We have determined a 1.18 Å resolution X-ray crystal structure of a novel ruthenocenyle-6-aminopenicillinic acid in complex with CTX-M β-lactamase, showing unprecedented details of interactions between ruthenocene and protein. As the first product complex with an intact catalytic serine, the structure also offers insights into β-lactamase catalysis and inhibitor design.

Was this content written or created while at USF?

Yes

Citation / Publisher Attribution

Chemical Communication, v. 51, 6186-6189

Scholar Commons Citation

Lewandowski, Eric M.; Skiba, Joanna; Torelli, Nicholas J.; Rajnisz, Aleksandra; Solecka, Jolanta; Kowalski, Konrad; and Chen, Yu, "Antibacterial Properties and Atomic Resolution X-ray Complex Crystal Structure of a Ruthenocene Conjugated β-lactam Antibiotic" (2015). Molecular Medicine Faculty Publications. 64.
https://digitalcommons.usf.edu/mme_facpub/64