Intrinsic Disorder in Proteins Associated with Neurodegenerative Diseases
Document Type
Article
Publication Date
2009
Digital Object Identifier (DOI)
https://doi.org/10.2741/3594
Abstract
Neurodegenerative diseases constitute a set of pathological conditions originating from the slow, irreversible and systematic cell loss within the various regions of the brain and/or the spinal cord. Neurodegenerative diseases are proteinopathies associated with misbehavior and disarrangement of a specific protein, affecting its processing, functioning, and/or folding. Many proteins associated with human neurodegenerative diseases are intrinsically disordered; i.e., they lack stable tertiary and/or secondary structure under physiological conditions in vitro. Intrinsically disordered proteins (IDPs) have broad presentation in nature. Functionally, they complement ordered proteins, being typically involved in regulation, signaling and control. Structures and functions of IDPs are intensively modulated by alternative splicing and posttranslational modifications. It is recognized now that nanoimaging offers a set of tools to analyze protein misfolding and self-assembly via monitoring the aggregation process, to visualize protein aggregates, and to analyze properties of these aggregates. The major goals of this review are to show the interconnections between intrinsic disorder and human neurodegenerative diseases and to overview a recent progress in development of novel nanoimaging tools to follow protein aggregation.
Was this content written or created while at USF?
Yes
Citation / Publisher Attribution
Frontiers in Bioscience-Landmark, v. 14, issue 14, p. 5188-5238
Scholar Commons Citation
Uversky, Vladimir N., "Intrinsic Disorder in Proteins Associated with Neurodegenerative Diseases" (2009). Molecular Medicine Faculty Publications. 616.
https://digitalcommons.usf.edu/mme_facpub/616
