Detection of Links Between Ebola Nucleocapsid and Virulence Using Disorder Analysis
Document Type
Article
Publication Date
2015
Digital Object Identifier (DOI)
https://doi.org/10.1039/C5MB00240K
Abstract
The underlying reasons for the differences in the virulence of various types of Ebola virus (EBOV) remain unknown. Comparison of the percentage of disorder (PID) in nucleocapsid proteins VP30 and NP reveals high correlation between nucleocapsid PIDs and the case-fatality rates of EBOV. The higher disorder of these proteins is likely to be needed for more efficient multiplication of virus copies via more efficient viral RNA transcription and more promiscuous protein binding potential. This is important for the more efficient assistance of nucleocapsid in viral particle budding and of the assembly and mobility of viral proteins across the host membrane and within the cytoplasm. A more comprehensive knowledge of the molecular mechanisms of EBOV virulence would also lead to new and more effective strategies in vaccine development.
Was this content written or created while at USF?
Yes
Citation / Publisher Attribution
Molecular BioSystems, v. 11, issue 8, p. 2337-2344
Scholar Commons Citation
Goh, Gerard Kian-Meng; Dunker, A. Keith; and Uversky, Vladimir N., "Detection of Links Between Ebola Nucleocapsid and Virulence Using Disorder Analysis" (2015). Molecular Medicine Faculty Publications. 596.
https://digitalcommons.usf.edu/mme_facpub/596
