Disorder in The Lifetime of a Protein
Document Type
Article
Publication Date
2013
Keywords
Intrinsically disordered protein region, Protein function, Nascent polypeptide chain, Protein degradation, Protein biosynthesis
Digital Object Identifier (DOI)
https://doi.org/10.4161%2Fidp.26782
Abstract
Intrinsic disorder is everywhere and is inevitable. The non-folding propensity is inherent for numerous natural polypeptide chains, and many functional proteins and protein regions are intrinsically disordered. Furthermore, at particular moments in their life, most notably during their synthesis and degradation, all ordered proteins are at least partially unfolded (disordered). Also, there is a widely spread phenomenon of conditional (functional or transient) disorder, where functions of many ordered proteins require local or even global unfolding of their unique structures. Finally, extrinsic disorder (i.e., intrinsic disorder in functional partners of ordered proteins) should be taken into account too. Therefore, even if a protein is completely devoid of intrinsically disordered regions in its mature form (which is a rather exceptional situation), it faces different forms of disorder (intrinsic, extrinsic, or induced disorder) at all the stages of its functional life, from birth to death. The goal of this article is to briefly introduce this concept of disorder in the lifetime of a protein.
Was this content written or created while at USF?
Yes
Citation / Publisher Attribution
Intrinsically Disord Proteins, v. 1, issue 1, arc. e26782
Scholar Commons Citation
Uversky, Vladimir N., "Disorder in The Lifetime of a Protein" (2013). Molecular Medicine Faculty Publications. 434.
https://digitalcommons.usf.edu/mme_facpub/434
