Document Type
Article
Publication Date
2015
Keywords
Intrinsically disordered proteins, Cell nucleus, Homo sapiens, Protein function, Nuclear proteins, Nuclear compartments
Digital Object Identifier (DOI)
https://doi.org/10.1016/j.bbrep.2015.03.003
Abstract
Intrinsically disordered proteins are known to perform a variety of important functions such as macromolecular recognition, promiscuous binding, and signaling. They are crucial players in various cellular pathway and processes, where they often have key regulatory roles. Among vital cellular processes intimately linked to the intrinsically disordered proteins is transcription, an intricate biological performance predominantly developing inside the cell nucleus. With this work, we gathered information about proteins that exist in various compartments and sub-nuclear bodies of the nucleus of the human cells, with the goal of identifying which ones are highly disordered and which functions are ascribed to the disordered nuclear proteins.
Rights Information
This work is licensed under a Creative Commons Attribution 4.0 License.
Was this content written or created while at USF?
Yes
Citation / Publisher Attribution
Biochemistry and Biophysics Reports, v. 1, p. 33-51
Scholar Commons Citation
Frege, Telma and Uversky, Vladimir N., "Intrinsically Disordered Proteins in the Nucleus of Human Cells" (2015). Molecular Medicine Faculty Publications. 389.
https://digitalcommons.usf.edu/mme_facpub/389
Supplementary Information
