On the Potential of Using Peculiarities of the Protein Intrinsic Disorder Distribution in Mitochondrial Cytochrome B to Identify the Source of Animal Meats

Document Type


Publication Date



adulteration, animal species, authentication, avian species, food products, intrinsically disordered protein, intrinsically disordered region, meat, mitochondrial cytochrome b

Digital Object Identifier (DOI)



This study was conducted to identify the source of animal meat based on the peculiarities of protein intrinsic disorder distribution in mitochondrial cytochrome b (mtCyt-b). The analysis revealed that animal and avian species can be discriminated based on the proportions of the two groups of residues, Leu+Ile, and Ser+Pro+Ala, in the amino acid sequences of their mtCyt-b. Although levels of the overall intrinsic disorder in mtCyt-b is not very high, the peculiarities of disorder distribution within the sequences of mtCyt-b from different species varies in a rather specific way. In fact, positions and intensities of disorder/flexibility “signals” in the corresponding disorder profiles are relatively unique for avian and animal species. Therefore, it is possible to devise a set of simple rules based on the peculiarities of disorder profiles of their mtCyt-b proteins to discriminate among species. This intrinsic disorder-based analysis represents a new technique that could be used to provide a promising solution for identification of the source of meats.

Was this content written or created while at USF?


Citation / Publisher Attribution

Intrinsically Disordered Proteins, v. 5, issue 5, art. e1264350