Document Type

Article

Publication Date

2016

Keywords

amino acids, polarity profile, pattern recognition, dynam-ical systems theory, atherosclerosis, selective antibacterial peptides, intrinsically disordered proteins

Digital Object Identifier (DOI)

https://doi.org/10.18388/abp.2014_919

Abstract

Proteins in the post-genome era impose diverse research challenges, the main are the understanding of their structure-function mechanism, and the growing need for new pharmaceutical drugs, particularly antibiotics that help clinicians treat the ever- increasing number of Multidrug-Resistant Organisms (MDROs). Although, there is a wide range of mathematical-computational algorithms to satisfy the demand, among them the Quantitative Structure-Activity Relationship algorithms that have shown better performance using a characteristic training data of the property searched; their performance has stagnated regardless of the number of metrics they evaluate and their complexity. This article reviews the characteristics of these metrics, and the need to reconsider the mathematical structure that expresses them, directing their design to a more comprehensive algebraic structure. It also shows how the main function of a protein can be determined by measuring the polarity of its linear sequence, with a high level of accuracy, and how such exhaustive metric stands as a "fingerprint" that can be applied to scan the protein regions to obtain new pharmaceutical drugs, and thus to establish how the singularities led to the specialization of the protein groups known today.

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Creative Commons License
This work is licensed under a Creative Commons Attribution-Share Alike 4.0 License.

Was this content written or created while at USF?

Yes

Citation / Publisher Attribution

Acta Biochimica Polonica, v. 63, issue 2, p. 229-233

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