DisProt 7.0: a Major Update of the Database of Disordered Proteins

Authors

• Damiano Piovesan, University of Padova
• Francesco Tabaro, University of Padova
• Ivan Mičetić, University of Padova
• Marco Necci, University of Padova
• Federica Quaglia, University of Padova
• Christopher J. Oldfield, Indiana University School of Medicine
• Maria Cristina Aspromonte, University of Padova
• Norman E. Davey, Conway Institute of Biomolecular & Biomedical Research
• Radoslav Davidović, Institute of Nuclear Sciences Vinca
• Zsuzsanna Dosztányi, Eötvös Loránd University
• Arne Elofsson, Stockholm University
• Alessandra Gasparini, University of Padova
• András Hatos, University of Padova
• Andrey V. Kajava, Centre de Recherche en Biologie cellulaire de Montpellier (CRBM), UMR 5237 CNRS, Université Montpellier 1919 Route de Mende, Cedex 5, Montpellier 34293, France
• Lajos Kalmar, Institute of Enzymology
• Emanuela Leonardi, University of Padova
• Tamas Lazar, Structural Biology Brussels, Vrije Universiteit Brussel (VUB), Brussels 1050, Belgium
• Sandra Macedo-Ribeiro, Biomolecular Structure and Function Group, Instituto de Biologia Molecular e Celular (IBMC) and Instituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto, 4200-135 Porto, Portugal
• Mauricio Macossay-Castillo, Structural Biology Brussels, Vrije Universiteit Brussel (VUB), Brussels 1050, Belgium
• Attila Meszaros, Institute of Enzymology
• Giovanni Minervini, University of Padova
• Nikoletta Murvai, Institute of Enzymology
• Jordi Pujols, Departament de Bioquimica i Biologia Molecular and Institut de Biotecnologia i Biomedicina, Universitat Autònoma de Barcelona, Bellaterra 08193, Spain
• Daniel B. Roche, Centre de Recherche en Biologie cellulaire de Montpellier (CRBM), UMR 5237 CNRS, Université Montpellier 1919 Route de Mende, Cedex 5, Montpellier 34293, France
• Edoardo Salladini, Aix-Marseille Univ, CNRS, AFMB, UMR 7257, Marseille, France
• Eva Schad, Institute of Enzymology
• Antoine Schramm, Aix-Marseille Univ, CNRS, AFMB, UMR 7257, Marseille, France
• Beata Szabo, Institute of Enzymology
• Agnes Tantos, Institute of Enzymology
• Fiorella Tonello, University of Padova
• Konstantinos D. Tsirigos, Stockholm University
• Nevena Veljković, Institute of Nuclear Sciences Vinca
• Salvador Ventura, Universitat Autònoma de Barcelona
• Wim Vranken, Structural Biology Brussels, Vrije Universiteit Brussel (VUB), Brussels 1050, Belgium
• Per Warholm, Stockholm University
• Vladimir N. Uversky, University of South FloridaFollow
• A. Keith Dunker, Indiana University School of Medicine
• Sonia Longhi, Aix-Marseille Univ, CNRS, AFMB, UMR 7257, Marseille, France
• Peter Tompa, Institute of Enzymology
• Silvio C.E. Tosatto, University of Padova

Document Type

Article

Publication Date

2017

Keywords

nuclear magnetic resonance, community

Digital Object Identifier (DOI)

https://doi.org/10.1093/nar/gkw1056

Abstract

The Database of Protein Disorder (DisProt, URL: www.disprot.org) has been significantly updated and upgraded since its last major renewal in 2007. The current release holds information on more than 800 entries of IDPs/IDRs, i.e. intrinsically disordered proteins or regions that exist and function without a well-defined three-dimensional structure. We have re-curated previous entries to purge DisProt from conflicting cases, and also upgraded the functional classification scheme to reflect continuous advance in the field in the past 10 years or so. We define IDPs as proteins that are disordered along their entire sequence, i.e. entirely lack structural elements, and IDRs as regions that are at least five consecutive residues without well-defined structure. We base our assessment of disorder strictly on experimental evidence, such as X-ray crystallography and nuclear magnetic resonance (primary techniques) and a broad range of other experimental approaches (secondary techniques). Confident and ambiguous annotations are highlighted separately. DisProt 7.0 presents classified knowledge regarding the experimental characterization and functional annotations of IDPs/IDRs, and is intended to provide an invaluable resource for the research community for a better understanding structural disorder and for developing better computational tools for studying disordered proteins.

Rights Information

This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License

Was this content written or created while at USF?

Yes

Citation / Publisher Attribution

Nucleic Acids Research, v. 45, issue D1, p. D219-D227

Scholar Commons Citation

Piovesan, Damiano; Tabaro, Francesco; Mičetić, Ivan; Necci, Marco; Quaglia, Federica; Oldfield, Christopher J.; Aspromonte, Maria Cristina; Davey, Norman E.; Davidović, Radoslav; Dosztányi, Zsuzsanna; Elofsson, Arne; Gasparini, Alessandra; Hatos, András; Kajava, Andrey V.; Kalmar, Lajos; Leonardi, Emanuela; Lazar, Tamas; Macedo-Ribeiro, Sandra; Macossay-Castillo, Mauricio; Meszaros, Attila; Minervini, Giovanni; Murvai, Nikoletta; Pujols, Jordi; Roche, Daniel B.; Salladini, Edoardo; Schad, Eva; Schramm, Antoine; Szabo, Beata; Tantos, Agnes; Tonello, Fiorella; Tsirigos, Konstantinos D.; Veljković, Nevena; Ventura, Salvador; Vranken, Wim; Warholm, Per; Uversky, Vladimir N.; Dunker, A. Keith; Longhi, Sonia; Tompa, Peter; and Tosatto, Silvio C.E., "DisProt 7.0: a Major Update of the Database of Disordered Proteins" (2017). Molecular Medicine Faculty Publications. 311.
https://digitalcommons.usf.edu/mme_facpub/311