Document Type
Article
Publication Date
2016
Keywords
Zika virus, Intrinsically disordered proteins (IDPs), intrinsically disordered protein regions (IDPRs), molecular machinery, viral proteome, Cellular proteome
Digital Object Identifier (DOI)
https://doi.org/10.3389/fcimb.2016.00144
Abstract
Over the last few decades, concepts of protein intrinsic disorder have been implicated in different biological processes. Recent studies have suggested that intrinsically disordered proteins (IDPs) provide structural plasticity and functional diversity to viral proteins that are involved in rapid replication and immune evasion in host cells. In case of Zika virus, the roles of protein intrinsic disorder in mechanisms of pathogenesis are not completely understood. In this study, we have analyzed the prevalence of intrinsic disorder in Zika virus proteome (strain MR 766). Our analyses revealed that Zika virus polyprotein is enriched with intrinsically disordered protein regions (IDPRs) and this finding is consistent with previous reports on the involvement of IDPs in shell formation and virulence of the Flaviviridae family. We found abundant IDPRs in Capsid, NS2B, NS3, NS4A, and NS5 proteins that are involved in mature particle formation and replication. In our view, the intrinsic disorder-focused analysis of ZIKV proteins could be important for the development of disorder-based drugs.
Rights Information
This work is licensed under a Creative Commons Attribution 4.0 License.
Was this content written or created while at USF?
Yes
Citation / Publisher Attribution
Frontiers in Cellular and Infection Microbiology, v. 6, art. 144
Scholar Commons Citation
Giri, Rajanish; Kumar, Deepak; Sharma, Nitin; and Uversky, Vladimir N., "Intrinsically Disordered Side of the Zika Virus Proteome" (2016). Molecular Medicine Faculty Publications. 294.
https://digitalcommons.usf.edu/mme_facpub/294
