Document Type
Article
Publication Date
2018
Keywords
Intrinsically disordered proteins, Viral proteins
Digital Object Identifier (DOI)
https://doi.org/10.1038/s41598-018-23969-0
Abstract
Chikungunya virus (CHIKV) is a mosquito-borne alphavirus. The outbreak of CHIKV infection has been seen in many tropical and subtropical regions of the biosphere. Current reports evidenced that after outbreaks in 2005–06, the fitness of this virus propagating in Aedes albopictus enhanced due to the epistatic mutational changes in its envelope protein. In our study, we evaluated the prevalence of intrinsically disordered proteins (IDPs) and IDP regions (IDPRs) in CHIKV proteome. IDPs/IDPRs are known as members of a ‘Dark Proteome’ that defined as a set of polypeptide segments or whole protein without unique three-dimensional structure within the cellular milieu but with significant biological functions, such as cell cycle regulation, control of signaling pathways, and maintenance of viral proteomes. However, the intrinsically disordered aspects of CHIKV proteome and roles of IDPs/IDPRs in the pathogenic mechanism of this important virus have not been evaluated as of yet. There are no existing reports on the analysis of intrinsic disorder status of CHIKV. To fulfil this goal, we have analyzed the abundance and functionality of IDPs/IDPRs in CHIKV proteins, involved in the replication and maturation. It is likely that these IDPs/IDPRs can serve as novel targets for disorder based drug design.
Rights Information
This work is licensed under a Creative Commons Attribution 4.0 License.
Was this content written or created while at USF?
Yes
Citation / Publisher Attribution
Scientific Reports, v. 8, art. 5822
Scholar Commons Citation
Singh, Ankur; Kumar, Ankur; Yadav, Rakhi; Uversky, Vladimir N.; and Giri, Rajanish, "Deciphering the Dark Proteome of Chikungunya Virus" (2018). Molecular Medicine Faculty Publications. 218.
https://digitalcommons.usf.edu/mme_facpub/218
Supplementary Information
