Document Type
Article
Publication Date
2020
Keywords
intrinsically disordered protein, intrinsically disordered protein region, protein function, structure-function continuum
Digital Object Identifier (DOI)
https://doi.org/10.12688/f1000research.20867.1
Abstract
Functions of intrinsically disordered proteins do not require structure. Such structure-independent functionality has melted away the classic rigid “lock and key” representation of structure–function relationships in proteins, opening a new page in protein science, where molten keys operate on melted locks and where conformational flexibility and intrinsic disorder, structural plasticity and extreme malleability, multifunctionality and binding promiscuity represent a new-fangled reality. Analysis and understanding of this new reality require novel tools, and some of the techniques elaborated for the examination of intrinsically disordered protein functions are outlined in this review.
Rights Information
This work is licensed under a Creative Commons Attribution 4.0 License.
Was this content written or created while at USF?
Yes
Citation / Publisher Attribution
F1000Research, v. 9, art. 101
Scholar Commons Citation
Uversky, Vladimir N., "New Technologies to Analyse Protein Function: An Intrinsic Disorder Perspective" (2020). Molecular Medicine Faculty Publications. 214.
https://digitalcommons.usf.edu/mme_facpub/214
