Comprehensive Analysis of the Molecular Docking of Small Molecule Inhibitors to the Aβ1–40 Peptide and Its Osaka-mutant: Insights into the Molecular Mechanisms of Aβ-peptide Inhibition

Document Type

Article

Publication Date

2020

Keywords

Alzheimer’s disease, amyloid beta peptide, Osaka-mutant, Iowa-mutant, polyphenols

Digital Object Identifier (DOI)

https://doi.org/10.1080/07391102.2019.1697367

Abstract

Alzheimer’s disease (AD) is the most common form of age-related neurodegeneration occurs because of deposition of proteins in the form of extracellular plaques containing aggregated amyloid beta (Aβ) peptide and intracellular neurofibrillary tangles composed of aggregated microtubule-binding protein tau. Amyloid aggregation process can be enhanced by several familial AD-associated mutations in Aβ peptide. In this study, we have unravelled the interactions of 40 small molecule inhibitors with the Osaka-mutant of Aβ1–40 peptide at atomic level and characterized modes of their binding to mutant Aβ by docking approaches. We have also compared docking energies of these inhibitors with Osaka-mutant with those previously determined for the wild-type and Iowa-mutant peptides and discussed in light of the peptide conformations and non-covalent interactions. We have also discussed inhibition mechanisms of these three peptides. Our analyses revealed that these small molecules can efficiently inhibit Osaka-mutant. The binding modes of drugs with these three peptides are markedly different and so are the mechanisms of inhibition of these three peptides. Overall analysis of the data reveals that binding energy of Iowa-mutant drug complex is lowest and most stable which is followed wild-type peptide-drug complex followed by Osaka-mutant drug complex.

Was this content written or created while at USF?

Yes

Citation / Publisher Attribution

Journal of Biomolecular Structure and Dynamics, v. 38, issue 15, p. 4536-4566

Link to Full Text

Share

COinS