Posttranslational Modification
Document Type
Book Chapter
Publication Date
2013
Keywords
Chemical Modifications, Intrinsically Disordered Proteins, Posttranslational Modifications, Protein Biosynthesis, Protein Folding, Protein Function, Protein Structure
Digital Object Identifier (DOI)
https://doi.org/10.1016/B978-0-12-374984-0.01203-1
Abstract
At the later stages of protein biosynthesis, after their transcription, many proteins undergo intensive chemical alterations, collectively known as protein posttranslational modifications (PTMs). These modifications are many and range from the proteolytic cleavage to the covalent attachment of diverse functional groups or even proteins to specific side chains of a target protein. PTMs change local physical and chemical properties of a polypeptide chain, modifying, for example, its charge, hydrophobicity, and flexibility. As a result, the functional diversity of the proteome is increased. Many PTMs are found within the highly mobile protein regions. Often, such chemical modifications and their alterations are directly associated with the pathogenesis of various human diseases.
Was this content written or created while at USF?
Yes
Citation / Publisher Attribution
Posttranslational Modification, in S. Maloy & K. Hughes, Reference Module in Life Sciences: Brenner's Encyclopedia of Genetics (Second Edition), Academic Press, p. 425-430
Scholar Commons Citation
Uversky, Vladimir N., "Posttranslational Modification" (2013). Molecular Medicine Faculty Publications. 1113.
https://digitalcommons.usf.edu/mme_facpub/1113
