Unfoldomes and Unfoldomics: Introducing Intrinsically Disordered Proteins
Document Type
Book Chapter
Publication Date
2016
Keywords
Intrinsically Disordered Protein, Protein Structure, Protein Function, Protein Dynamics, Protein-protein Interactions, Posttranslational Modification, Alternative Splicing, Protein Misfolding
Digital Object Identifier (DOI)
https://doi.org/10.1007/978-4-431-55840-8_6
Abstract
The last decade and a half has witnessed the fall of one of the major paradigms in structural biology. Contrary to the more than a hundred year-old belief that unique protein function is defined by unique crystal-like protein structure which is encoded in unique amino acid sequence, many biologically active proteins lack stable tertiary and/or secondary structure under physiological conditions in vitro. These intrinsically disordered proteins (IDPs) and IDP regions (IDPRs) are very different from ordered proteins and domains at the variety of levels, starting from the specific and well-recognizable amino acid composition and sequence biases and ending with engagement in biological functions non-accessible to entities with unique and fixed structures. IDPs/IDPRs are highly abundant in nature, and many of them are associated with various human diseases. The functional repertoire of IDPs complements the functions of ordered proteins, with IDPs being often involved in regulation, signaling, and control. Due to their exceptional commonness within the protein universe, combined with a set of specific structural and conformational features, and broad and unique functional repertoire, IDPs and hybrid proteins possessing ordered domains and functional IDPRs clearly comprise unfoldomes within all known proteomes. This chapter provides a brief description of IDPs/IDPRs and shows the place of these exceptionally interesting creatures within the protein kingdom.
Was this content written or created while at USF?
Yes
Citation / Publisher Attribution
Unfoldomes and Unfoldomics: Introducing Intrinsically Disordered Proteins, in M. Terazima, M. Kataoka, R. Ueoka & Y. Okamoto (Eds.), Molecular Science of Fluctuations Toward Biological Functions, Springer, p. 125-150
Scholar Commons Citation
Xue, Bin and Uversky, Vladimir N., "Unfoldomes and Unfoldomics: Introducing Intrinsically Disordered Proteins" (2016). Molecular Medicine Faculty Publications. 1100.
https://digitalcommons.usf.edu/mme_facpub/1100
