New Directions in Systemic Therapy of Pancreatic Cancer
Document Type
Article
Publication Date
2000
Digital Object Identifier (DOI)
https://doi.org/10.1177/107327480000700506
Abstract
Background: The aggressiveness of pancreatic adenocarcinoma makes it a deadly disease, with its incidence rate and fatality rate almost equal. Surgery represents the only means to provide cure to patients with pancreatic cancer, though the 5-year survival is less than 10%.
Methods: We review the data on surgical and systemic therapies and provide more details on a newer biologically based medical approach.
Results: Neoadjuvant chemotherapy protocols are confined to one or two institutions, and adjuvant chemotherapy and chemoradiation therapy protocols are far from being standardized. Chemoradiation therapy for locally advanced pancreatic cancer offers limited benefits. Protocols that include gemcitabine and 5-fluorouracil, while comparing favorably to historical controls, offer median survivals at approximately 8 months.
Conclusions: More effective protocols with combinations of approaches agents are needed to improve the treatment of pancreatic cancer.
Was this content written or created while at USF?
Yes
Citation / Publisher Attribution
Cancer Control, v. 7, issue 5, p. 437-444
Scholar Commons Citation
Rosemurgy, Alexander S. and Serafini, Francesco M., "New Directions in Systemic Therapy of Pancreatic Cancer" (2000). Communication Sciences and Disorders Faculty Publications. 33.
https://digitalcommons.usf.edu/csd_facpub/33
