Nano‐Sized Lipidated Dendrimers as Potent and Broad‐Spectrum Antibacterial Agents
Document Type
Article
Publication Date
12-2018
Keywords
amphipathic, asymmetric, dendrimers, host defense peptides, lipid tails
Digital Object Identifier (DOI)
https://doi.org/10.1002/marc.201800622
Abstract
There is considerable interest in the development of antimicrobial polymers including dendrimers due to the ease of synthesis and low manufacturing cost compared to host defense peptides (HDPs). Herein, a new class of nanomaterials—lipidated amphiphilic dendrimers—is presented that mimic the antibacterial mechanism of HDPs by compromising bacterial cell membranes. Unlike conventional dendrimers that are prepared generation by generation symmetrically with molecular weight distribution, these lipidated dendrimers are prepared on the solid phase with a hanging lipid tail and precisely controlled structure. It is shown through rational design that these lipidated dendrimers display potent and selective antimicrobial activity against both Gram‐positive and Gram‐negative bacteria, including multidrug‐resistant strains. In addition to antibacterial activity against planktonic bacteria, these dendrimers are also shown to inhibit bacterial biofilms effectively. This class of dendrimers as a new class of biomaterials may lead to a useful generation of antibiotic agents with practical applications.
Was this content written or created while at USF?
Yes
Citation / Publisher Attribution
Macromolecular Rapid Communications, v. 39, issue 24, art. 1800622
Scholar Commons Citation
Gide, Mussie; Nimmagadda, Alekhya; Su, Ma; Wang, Minghui; Teng, Peng; Li, Chunpu; Gao, Ruixuan; Xu, Hai; Li, Qi; and Cai, Jianfeng, "Nano‐Sized Lipidated Dendrimers as Potent and Broad‐Spectrum Antibacterial Agents" (2018). Chemistry Faculty Publications. 49.
https://digitalcommons.usf.edu/chm_facpub/49
