Document Type
Article
Publication Date
5-2018
Digital Object Identifier (DOI)
https://doi.org/10.1038/s41467-018-04247-z
Abstract
Nested concentric structures widely exist in nature and designed systems with circles, polygons, polyhedra, and spheres sharing the same center or axis. It still remains challenging to construct discrete nested architecture at (supra)molecular level. Herein, three generations (G2−G4) of giant nested supramolecules, or Kandinsky circles, have been designed and assembled with molecular weight 17,964, 27,713 and 38,352 Da, respectively. In the ligand preparation, consecutive condensation between precursors with primary amines and pyrylium salts is applied to modularize the synthesis. These discrete nested supramolecules are prone to assemble into tubular nanostructures through hierarchical self-assembly. Furthermore, nested supramolecules display high antimicrobial activity against Gram-positive pathogen methicillin-resistant Staphylococcus aureus (MRSA), and negligible toxicity to eukaryotic cells, while the corresponding ligands do not show potent antimicrobial activity.
Rights Information
This work is licensed under a Creative Commons Attribution 4.0 License.
Was this content written or created while at USF?
Yes
Citation / Publisher Attribution
Nature Communications, v. 9, art. 1815
Scholar Commons Citation
Wang, Heng; Qian, Xiaomin; Wang, Kun; Su, Ma; Haoyang, Wei-Wei; Jiang, Xin; Brzozowski, Robert S.; Li, Yiming; Eswara, Prahathees J.; Cai, Jianfeng; and Li, Xiaopeng, "Supramolecular Kandinsky Circles with High Antibacterial Activity" (2018). Chemistry Faculty Publications. 46.
https://digitalcommons.usf.edu/chm_facpub/46
Comments
Complete list of authors: Ming Wang, Xiang Gao, Bingqian Xu, Xin-Qi Hao, Weitao Gong, Jun-Li Hou