Supramolecular Kandinsky Circles with High Antibacterial Activity

Authors

Heng Wang, University of South FloridaFollow
Xiaomin Qian, University of South Florida
Kun Wang, University of Georgia
Ma Su, University of South Florida
Wei-Wei Haoyang, Fudan University
Xin Jiang, Jilin University
Robert S. Brzozowski, University of South FloridaFollow
Yiming Li, University of South FloridaFollow
Prahathees J. Eswara, University of South FloridaFollow
Jianfeng Cai, University of South FloridaFollow
Xiaopeng Li, University of South FloridaFollow

Document Type

Article

Publication Date

5-2018

Digital Object Identifier (DOI)

https://doi.org/10.1038/s41467-018-04247-z

Abstract

Nested concentric structures widely exist in nature and designed systems with circles, polygons, polyhedra, and spheres sharing the same center or axis. It still remains challenging to construct discrete nested architecture at (supra)molecular level. Herein, three generations (G2−G4) of giant nested supramolecules, or Kandinsky circles, have been designed and assembled with molecular weight 17,964, 27,713 and 38,352 Da, respectively. In the ligand preparation, consecutive condensation between precursors with primary amines and pyrylium salts is applied to modularize the synthesis. These discrete nested supramolecules are prone to assemble into tubular nanostructures through hierarchical self-assembly. Furthermore, nested supramolecules display high antimicrobial activity against Gram-positive pathogen methicillin-resistant Staphylococcus aureus (MRSA), and negligible toxicity to eukaryotic cells, while the corresponding ligands do not show potent antimicrobial activity.

Comments

Complete list of authors: Ming Wang, Xiang Gao, Bingqian Xu, Xin-Qi Hao, Weitao Gong, Jun-Li Hou

Rights Information

This work is licensed under a Creative Commons Attribution 4.0 License.

Was this content written or created while at USF?

Yes

Citation / Publisher Attribution

Nature Communications, v. 9, art. 1815

Scholar Commons Citation

Wang, Heng; Qian, Xiaomin; Wang, Kun; Su, Ma; Haoyang, Wei-Wei; Jiang, Xin; Brzozowski, Robert S.; Li, Yiming; Eswara, Prahathees J.; Cai, Jianfeng; and Li, Xiaopeng, "Supramolecular Kandinsky Circles with High Antibacterial Activity" (2018). Chemistry Faculty Publications. 46.
https://digitalcommons.usf.edu/chm_facpub/46