Document Type
Article
Publication Date
5-2018
Digital Object Identifier (DOI)
https://doi.org/10.1038/s41467-018-04331-4
Abstract
Transition-metal-catalyzed diazo activation is a classical way to generate metal carbene, which are valuable intermediates in synthetic organic chemistry. An alternative iodine-catalyzed diazo activation is disclosed herein under either photo-initiated or thermal-initiated conditions, which represents an approach to enable carbene radical reactivity. This metal-free diazo activation strategy were successfully applied into olefin cyclopropanation and epoxidation, and applying this method to pyrrole synthesis under thermal-initiated conditions further demonstrates the unique reactivity using this method over typical metal-catalyzed conditions.
Rights Information
This work is licensed under a Creative Commons Attribution 4.0 License.
Was this content written or created while at USF?
Yes
Citation / Publisher Attribution
Nature Communications, v. 9, art. 1972
Scholar Commons Citation
Li, Pan; Zhao, Jingjing; Shi, Lijun; Wang, Jin; Shi, Xiaodong; and Li, Fuwei, "Iodine-Catalyzed Diazo Activation to Access Radical Reactivity" (2018). Chemistry Faculty Publications. 45.
https://digitalcommons.usf.edu/chm_facpub/45
