Novel Bis-cyclic Guanidines as Potent Membrane-active Antibacterial Agents with Therapeutic Potential

Authors

Peng Teng, University of South Florida
Alekhya Nimmagadda, University of South Florida
Ma Su, University of South Florida
Yuzhu Hong, University of South Florida
Ning Shen, University of South Florida
Chunpu Li, University of South Florida
Ling-Yu Tsai, University of South Florida
Jessica Cao, University of South Florida
Qi Li, Shanghai University of Traditional Chinese Medicine
Jianfeng Cai, University of South FloridaFollow

Document Type

Article

Publication Date

2017

Digital Object Identifier (DOI)

https://doi.org/10.1039/C7CC07285F

Abstract

We designed a class of small dimeric cyclic guanidine derivatives which display potent antibacterial activity against both multidrug-resistant Gram-negative and Gram-positive bacteria. They could compromise bacterial membranes without developing resistance, inhibit biofilms formed by E. coli, and exhibit excellent in vivo activity in the MRSA-infected thigh burden mouse model.

Was this content written or created while at USF?

Yes

Citation / Publisher Attribution

Chemical Communication, v. 53, p. 11948-11951

Scholar Commons Citation

Teng, Peng; Nimmagadda, Alekhya; Su, Ma; Hong, Yuzhu; Shen, Ning; Li, Chunpu; Tsai, Ling-Yu; Cao, Jessica; Li, Qi; and Cai, Jianfeng, "Novel Bis-cyclic Guanidines as Potent Membrane-active Antibacterial Agents with Therapeutic Potential" (2017). Chemistry Faculty Publications. 215.
https://digitalcommons.usf.edu/chm_facpub/215