Identification of a Hit Series of Antileishmanial Compounds through the Use of Mixture-Based Libraries
Digital Object Identifier (DOI)
From a screening campaign that included mixture-based libraries containing more than 6 million compounds, a lead series of bis-cyclic guanidines was identified as the most promising. Lead optimization resulted in the identification of potent (IC50 < 500 nM) and selective compounds within this series as well as potent and selective monoguanidines.
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Citation / Publisher Attribution
ACS Medicinal Chemistry Letters, v. 8, issue 8, p. 802-807
Scholar Commons Citation
Giulianotti, Marc A.; Vesely, Brian A.; Azhari, Ala; Souza, Ashley; LaVoi, Travis; Houghten, Richard A.; Kyle, Dennis E.; and Leahy, James W., "Identification of a Hit Series of Antileishmanial Compounds through the Use of Mixture-Based Libraries" (2017). Chemistry Faculty Publications. 182.