Title

Identification of a Hit Series of Antileishmanial Compounds through the Use of Mixture-Based Libraries

Document Type

Article

Publication Date

2017

Digital Object Identifier (DOI)

https://doi.org/10.1021/acsmedchemlett.7b00045

Abstract

From a screening campaign that included mixture-based libraries containing more than 6 million compounds, a lead series of bis-cyclic guanidines was identified as the most promising. Lead optimization resulted in the identification of potent (IC50 < 500 nM) and selective compounds within this series as well as potent and selective monoguanidines.

Was this content written or created while at USF?

Yes

Citation / Publisher Attribution

ACS Medicinal Chemistry Letters, v. 8, issue 8, p. 802-807

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